[(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-sulfamic acid 2-hydroxy-phenyl ester

Base Information

Chemical Name:[(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-sulfamic acid 2-hydroxy-phenyl ester
CAS No.:193894-18-7
Molecular Formula:C₂₂H₃₃N₃O₈SSi
Molecular Weight:527.671
Hs Code.:

[(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-sulfamic acid 2-hydroxy-phenyl ester

Synonyms:[(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-sulfamic acid 2-hydroxy-phenyl ester

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Chemical Property of [(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-sulfamic acid 2-hydroxy-phenyl ester

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Technology Process of [(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-sulfamic acid 2-hydroxy-phenyl ester

There total 4 articles about [(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-sulfamic acid 2-hydroxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 4074-55-9
1,3,2-benzdioxathiole-2,2-dioxide

: 130128-70-0
5'-amino-3'-O-(tert-butyldimethylsilyl)-5’-deoxythymidine

: 193894-18-7
[(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-sulfamic acid 2-hydroxy-phenyl ester

Guidance literature:: With triethylamine;
DOI:10.1016/S0040-4039(97)01179-9

Reference yield:

: 132101-17-8
5′-azide-3′-O-tert-butyldimethylsilyl deoxythymidine

: 193894-18-7
[(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-sulfamic acid 2-hydroxy-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10 percent Pd-C

2: 63 percent / Et₃N

With hydrogen; triethylamine; palladium on activated charcoal;
DOI:10.1016/S0040-4039(97)01179-9

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 193894-18-7
[(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-sulfamic acid 2-hydroxy-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N

2: H₂ / 10 percent Pd-C

3: 63 percent / Et₃N

With hydrogen; triethylamine; palladium on activated charcoal;
DOI:10.1016/S0040-4039(97)01179-9