N⁵-acetyl-N⁵-(benzyloxy)-N²-(benzyloxycarbonyl)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-L-seryl-1,4-dibenzyl-D-aspartate

Base Information

• Chemical Name: N⁵-acetyl-N⁵-(benzyloxy)-N²-(benzyloxycarbonyl)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-L-seryl-1,4-dibenzyl-D-aspartate
• CAS No.: 130761-77-2
• Molecular Formula: C₇₁H₈₄N₈O₁₇
• Molecular Weight: 1321.49

Synonyms:N⁵-acetyl-N⁵-(benzyloxy)-N²-(benzyloxycarbonyl)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-L-seryl-1,4-dibenzyl-D-aspartate

Chemical Property of N⁵-acetyl-N⁵-(benzyloxy)-N²-(benzyloxycarbonyl)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-L-seryl-1,4-dibenzyl-D-aspartate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁵-acetyl-N⁵-(benzyloxy)-N²-(benzyloxycarbonyl)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-L-seryl-1,4-dibenzyl-D-aspartate

There total 17 articles about N⁵-acetyl-N⁵-(benzyloxy)-N²-(benzyloxycarbonyl)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-L-seryl-1,4-dibenzyl-D-aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

(N5-acetyl-N5-(benzyloxy)-N2-(benzyloxycarbonyl)-L-ornithyl)-(N5-acetyl-N5-(benzyloxy)-L-ornithyl)-N5-acetyl-N5-(benzyloxy)-L-ornithine (124620-56-0) + (R)-2-((S)-2-Amino-3-hydroxy-propionylamino)-succinic acid dibenzyl ester → N5-acetyl-N5-(benzyloxy)-N2-(benzyloxycarbonyl)-L-ornithyl-N5-acetyl-N5-(benzyloxy)-L-ornithyl-N5-acetyl-N5-(benzyloxy)-L-ornithyl-L-seryl-1,4-dibenzyl-D-aspartate (130761-77-2)

Guidance literature:

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane;

DOI:10.1021/jm00107a013

Reference yield:

Cbz-L-pGlu-OH (32159-21-0) → N5-acetyl-N5-(benzyloxy)-N2-(benzyloxycarbonyl)-L-ornithyl-N5-acetyl-N5-(benzyloxy)-L-ornithyl-N5-acetyl-N5-(benzyloxy)-L-ornithyl-L-seryl-1,4-dibenzyl-D-aspartate (130761-77-2)

Guidance literature:

Multi-step reaction with 14 steps

1: 70percent perchloric acid / Ambient temperature

2: 100 percent / 1 M KOH / methanol

3: triethylamine / tetrahydrofuran / 1 h / 0 °C

4: sodium borohydride / tetrahydrofuran; H₂O / 4 h / Ambient temperature

5: 71 percent / triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran / Ambient temperature

6: 81 percent / Zn, AcOH / 3 h / Irradiation

7: 100 percent / trifluoroacetic acid / 0.5 h / Ambient temperature

8: 54 percent / acetonitrile / 60 °C

9: 30percent HBr / CH₂Cl₂; acetic acid / 0.17 h

10: 2-ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline (EEDQ) / CH₂Cl₂

11: 66 percent / O-benzylhydroxylamine, Pd(PPh₃)4 / CH₂Cl₂ / 5 h

12: 2-ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline (EEDQ) / CH₂Cl₂

13: 74 percent / O-benzylhydroxylamine, Pd(PPh₃)4 / CH₂Cl₂ / 5 h

14: 54 percent / 2-ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline (EEDQ) / CH₂Cl₂

With potassium hydroxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; perchloric acid; N-benzyloxyamine; di-isopropyl azodicarboxylate; hydrogen bromide; acetic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; triphenylphosphine; trifluoroacetic acid; zinc; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; acetonitrile;

DOI:10.1021/jm00107a013

Reference yield:

N-(benzyloxycarbonyl)-L-glutamic acid anhydride (4124-76-9) → N5-acetyl-N5-(benzyloxy)-N2-(benzyloxycarbonyl)-L-ornithyl-N5-acetyl-N5-(benzyloxy)-L-ornithyl-N5-acetyl-N5-(benzyloxy)-L-ornithyl-L-seryl-1,4-dibenzyl-D-aspartate (130761-77-2)

Guidance literature:

Multi-step reaction with 15 steps

1: dicyclohexylamine (DCHA) / tetrahydrofuran / 0 °C

2: 70percent perchloric acid / Ambient temperature

3: 100 percent / 1 M KOH / methanol

4: triethylamine / tetrahydrofuran / 1 h / 0 °C

5: sodium borohydride / tetrahydrofuran; H₂O / 4 h / Ambient temperature

6: 71 percent / triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran / Ambient temperature

7: 81 percent / Zn, AcOH / 3 h / Irradiation

8: 100 percent / trifluoroacetic acid / 0.5 h / Ambient temperature

9: 54 percent / acetonitrile / 60 °C

10: 30percent HBr / CH₂Cl₂; acetic acid / 0.17 h

11: 2-ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline (EEDQ) / CH₂Cl₂

12: 66 percent / O-benzylhydroxylamine, Pd(PPh₃)4 / CH₂Cl₂ / 5 h

13: 2-ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline (EEDQ) / CH₂Cl₂

14: 74 percent / O-benzylhydroxylamine, Pd(PPh₃)4 / CH₂Cl₂ / 5 h

15: 54 percent / 2-ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline (EEDQ) / CH₂Cl₂

With potassium hydroxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; perchloric acid; N-benzyloxyamine; di-isopropyl azodicarboxylate; hydrogen bromide; acetic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; N-cyclohexyl-cyclohexanamine; triphenylphosphine; trifluoroacetic acid; zinc; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; acetonitrile;

DOI:10.1021/jm00107a013

upstream raw materials:

(N⁵-acetyl-N⁵-(benzyloxy)-N²-(benzyloxycarbonyl)-L-ornithyl)-(N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl)-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithine

N-benzyloxycarbonyl-L-glutamic acid

(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester

Cbz-L-pGlu-OH

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 130761-77-2 N⁵-acetyl-N⁵-(benzyloxy)-N²-(benzyloxycarbonyl)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl-L-seryl-1,4-dibenzyl-D-aspartate

Send

Send

Metric Ton KG G Pound L ML

Send

Send