2-(5-chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-yl)-4,5-dihydro-1H-imidazole

Base Information

Chemical Name:2-(5-chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-yl)-4,5-dihydro-1H-imidazole
CAS No.:1449332-87-9
Molecular Formula:C₁₇H₁₁ClF₂N₂O
Molecular Weight:332.737
Hs Code.:

Synonyms:2-(5-chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-yl)-4,5-dihydro-1H-imidazole

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Chemical Property of 2-(5-chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-yl)-4,5-dihydro-1H-imidazole

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Technology Process of 2-(5-chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-yl)-4,5-dihydro-1H-imidazole

There total 5 articles about 2-(5-chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-yl)-4,5-dihydro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1449332-86-8
5-chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-carbaldehyde

: 107-15-3,85404-18-8
ethylenediamine

: 1449332-87-9
2-(5-chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-yl)-4,5-dihydro-1H-imidazole

Guidance literature:: 5-chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-carbaldehyde; ethylenediamine; In tert-butyl alcohol; at 20 ℃; for 0.5h; Inert atmosphere;

With iodine; potassium carbonate; In tert-butyl alcohol; at 70 ℃; for 2h;

Reference yield:

: 1402004-77-6
1-chloro-2-fluoro-3-iodo-4-methoxybenzene

: 1449332-87-9
2-(5-chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-yl)-4,5-dihydro-1H-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium diacetate; triethylamine / water; acetonitrile / 5.16 h / 70 - 80 °C / Inert atmosphere; Large scale

2.1: N-iodo-succinimide; boron trifluoride diethyl etherate / dichloromethane / 1.08 h / 15 - 30 °C / Inert atmosphere; Large scale

3.1: n-butyllithium / tetrahydrofuran / 1 h / 78 °C / Inert atmosphere

3.2: 3 h

4.1: tert-butyl alcohol / 0.5 h / 20 °C / Inert atmosphere

4.2: 2 h / 70 °C

With N-iodo-succinimide; n-butyllithium; boron trifluoride diethyl etherate; palladium diacetate; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1449332-84-6
1-chloro-2-fluoro-3-((4-fluorophenyl)ethynyl)-4-methoxybenzene

: 1449332-87-9
2-(5-chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-yl)-4,5-dihydro-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-iodo-succinimide; boron trifluoride diethyl etherate / dichloromethane / 1.08 h / 15 - 30 °C / Inert atmosphere; Large scale

2.1: n-butyllithium / tetrahydrofuran / 1 h / 78 °C / Inert atmosphere

2.2: 3 h

3.1: tert-butyl alcohol / 0.5 h / 20 °C / Inert atmosphere

3.2: 2 h / 70 °C

With N-iodo-succinimide; n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;