(5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-aminoisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

Base Information

Chemical Name:(5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-aminoisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone
CAS No.:1202921-41-2
Molecular Formula:C₂₇H₂₂ClF₂N₃O₄
Molecular Weight:525.939
Hs Code.:

Synonyms:(5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-aminoisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

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Chemical Property of (5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-aminoisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

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Technology Process of (5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-aminoisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

There total 6 articles about (5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-aminoisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1202921-40-1
(5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

: 1202921-41-2
(5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-aminoisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

Guidance literature:: With water; ammonium chloride; zinc; In tetrahydrofuran; at 0 ℃; for 0.75h;
DOI:10.1021/jm201155e

Reference yield:

: 747413-04-3
5-(2,4-bis(benzyloxy)-5-chlorophenyl)isoxazole-3-carboxylic acid ethyl ester

: 1202921-41-2
(5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-aminoisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: water; lithium hydroxide / methanol / 24 h / 50 - 60 °C

2: thionyl chloride / 4 h / 80 °C / Inert atmosphere

3: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4: nitric acid; acetic anhydride / 70 h / 0 - 10 °C / Inert atmosphere

5: water; ammonium chloride; zinc / tetrahydrofuran / 0.75 h / 0 °C

With thionyl chloride; water; nitric acid; acetic anhydride; ammonium chloride; triethylamine; lithium hydroxide; zinc; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm201155e

Reference yield:

: C₂₄H₁₇Cl₂NO₄

: 1202921-41-2
(5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-aminoisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2: nitric acid; acetic anhydride / 70 h / 0 - 10 °C / Inert atmosphere

3: water; ammonium chloride; zinc / tetrahydrofuran / 0.75 h / 0 °C

With water; nitric acid; acetic anhydride; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm201155e