(5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

Base Information

Chemical Name:(5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone
CAS No.:1202921-40-1
Molecular Formula:C₂₇H₂₀ClF₂N₃O₆
Molecular Weight:555.922
Hs Code.:

Synonyms:(5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

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Chemical Property of (5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

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Technology Process of (5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

There total 5 articles about (5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 747413-04-3
5-(2,4-bis(benzyloxy)-5-chlorophenyl)isoxazole-3-carboxylic acid ethyl ester

: 1202921-40-1
(5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: water; lithium hydroxide / methanol / 24 h / 50 - 60 °C

2: thionyl chloride / 4 h / 80 °C / Inert atmosphere

3: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4: nitric acid; acetic anhydride / 70 h / 0 - 10 °C / Inert atmosphere

With thionyl chloride; water; nitric acid; acetic anhydride; triethylamine; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1021/jm201155e

Reference yield:

: C₂₄H₁₇Cl₂NO₄

: 1202921-40-1
(5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2: nitric acid; acetic anhydride / 70 h / 0 - 10 °C / Inert atmosphere

With nitric acid; acetic anhydride; triethylamine; In dichloromethane;
DOI:10.1021/jm201155e

Reference yield:

: 1202921-39-8
(5-(2,4-bis(benzyloxy)-5-chlorophenyl)-isoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

: 1202921-40-1
(5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

Guidance literature:: With nitric acid; acetic anhydride; at 0 - 10 ℃; for 70h; chemoselective reaction; Inert atmosphere;
DOI:10.1021/jm201155e