1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2,3,4-tetrahydro-[1,7]naphthyridine-6-carboxylic acid methyl ester

Base Information

Chemical Name:1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2,3,4-tetrahydro-[1,7]naphthyridine-6-carboxylic acid methyl ester
CAS No.:1392839-59-6
Molecular Formula:C₂₃H₂₀N₂O₄
Molecular Weight:388.423
Hs Code.:

Synonyms:1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2,3,4-tetrahydro-[1,7]naphthyridine-6-carboxylic acid methyl ester

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Chemical Property of 1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2,3,4-tetrahydro-[1,7]naphthyridine-6-carboxylic acid methyl ester

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Technology Process of 1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2,3,4-tetrahydro-[1,7]naphthyridine-6-carboxylic acid methyl ester

There total 8 articles about 1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2,3,4-tetrahydro-[1,7]naphthyridine-6-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392842-13-5
1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acidmethylamide

: 1392839-59-6
1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2,3,4-tetrahydro-[1,7]naphthyridine-6-carboxylic acid methyl ester

Guidance literature:: With hydrogen; sodium acetate; palladium 10% on activated carbon; In tetrahydrofuran; for 120h; under 1810.07 Torr;

Reference yield:

: 100-46-9
benzylamine

: 1392839-59-6
1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2,3,4-tetrahydro-[1,7]naphthyridine-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: methanol / 2 h / Reflux

1.2: 48 h / Reflux

2.1: sodium methylate; N-Bromosuccinimide / methanol / 1 h / Reflux

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 72 h / 20 °C

5.1: sodium methylate / methanol / 5 h

6.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

7.1: ethanol; tetrahydrofuran / 16 h / 80 °C / sealed tube

8.1: hydrogen; sodium acetate / palladium 10% on activated carbon / tetrahydrofuran / 120 h / 1810.07 Torr

With N-Bromosuccinimide; hydrogen; sodium methylate; sodium acetate; potassium carbonate; sodium iodide; dibenzoyl peroxide; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1392838-68-4
1-benzyl-3-bromo-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylic acid methyl ester

: 1392839-59-6
1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2,3,4-tetrahydro-[1,7]naphthyridine-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

2: ethanol; tetrahydrofuran / 16 h / 80 °C / sealed tube

3: hydrogen; sodium acetate / palladium 10% on activated carbon / tetrahydrofuran / 120 h / 1810.07 Torr

With hydrogen; sodium acetate; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;