1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acidmethylamide

Base Information

Chemical Name:1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acidmethylamide
CAS No.:1392842-13-5
Molecular Formula:C₂₃H₁₉N₃O₃
Molecular Weight:385.422
Hs Code.:

Synonyms:1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acidmethylamide

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Chemical Property of 1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acidmethylamide

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Technology Process of 1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acidmethylamide

There total 7 articles about 1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acidmethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392838-76-4
1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]-naphthyridine-6-carboxylic acid methyl ester

: 74-89-5
methylamine

: 1392842-13-5
1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acidmethylamide

Guidance literature:: In tetrahydrofuran; ethanol; at 80 ℃; for 16h; sealed tube;

Reference yield:

: 100-46-9
benzylamine

: 1392842-13-5
1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acidmethylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanol / 2 h / Reflux

1.2: 48 h / Reflux

2.1: sodium methylate; N-Bromosuccinimide / methanol / 1 h / Reflux

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 72 h / 20 °C

5.1: sodium methylate / methanol / 5 h

6.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

7.1: ethanol; tetrahydrofuran / 16 h / 80 °C / sealed tube

With N-Bromosuccinimide; sodium methylate; potassium carbonate; sodium iodide; dibenzoyl peroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 420087-95-2
4-(1-benzylamino-ethylidene)-pent-2-enedioic acid dimethyl ester

: 1392842-13-5
1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acidmethylamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium methylate; N-Bromosuccinimide / methanol / 1 h / Reflux

2: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

3: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 72 h / 20 °C

4: sodium methylate / methanol / 5 h

5: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

6: ethanol; tetrahydrofuran / 16 h / 80 °C / sealed tube

With N-Bromosuccinimide; sodium methylate; potassium carbonate; sodium iodide; dibenzoyl peroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; N,N-dimethyl-formamide;