methyl 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoate

Base Information

• Chemical Name: methyl 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoate
• CAS No.: 1103931-51-6
• Molecular Formula: C₃₅H₄₀ClN₃O₄
• Molecular Weight: 602.173

Synonyms:methyl 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoate

Chemical Property of methyl 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoate

Chemical Property:

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Technology Process of methyl 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoate

There total 3 articles about methyl 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[1-(2-{[4-chloro-2-(methoxycarbonyl)phenyl]amino}-2-oxoethyl)cyclohexyl]acetic acid (1103931-50-5) + diphenylmethylpiperazine (841-77-0) → methyl 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoate (1103931-51-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; at 0 - 20 ℃; for 2h;

DOI:10.1248/cpb.59.215

Reference yield:

4-chlorobenzenesulfonyl chloride (5202-89-1) → methyl 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoate (1103931-51-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 35 h / Reflux

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 2 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl acetamide;

DOI:10.1248/cpb.59.215

Reference yield:

1,1-cyclohexanediacetic acid anhydride (1010-26-0) → methyl 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoate (1103931-51-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 35 h / Reflux

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 2 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl acetamide;

DOI:10.1248/cpb.59.215

upstream raw materials:

4-chlorobenzenesulfonyl chloride

[1-(2-{[4-chloro-2-(methoxycarbonyl)phenyl]amino}-2-oxoethyl)cyclohexyl]acetic acid

diphenylmethylpiperazine

1,1-cyclohexanediacetic acid anhydride

Downstream raw materials:

5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoic acid hydrochloride

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