5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoic acid hydrochloride

Base Information

Chemical Name:5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoic acid hydrochloride
CAS No.:1103927-92-9
Molecular Formula:C₃₄H₃₈ClN₃O₄*ClH
Molecular Weight:624.607
Hs Code.:

Synonyms:5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoic acid hydrochloride

Suppliers and Price of 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoic acid hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoic acid hydrochloride

There total 5 articles about 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1103931-51-6
methyl 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoate

: 1103927-92-9
5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoic acid hydrochloride

Guidance literature:: methyl 5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoate; With water; sodium hydroxide; In tetrahydrofuran; at 60 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; water;
DOI:10.1248/cpb.59.215

Reference yield: 59.0%

: 1103927-92-9
5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoic acid hydrochloride

Guidance literature:

Reference yield:

: 5202-89-1
4-chlorobenzenesulfonyl chloride

: 1103927-92-9
5-chloro-2-[([1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclohexyl]acetyl)amino]benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 35 h / Reflux

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 2 h / 0 - 20 °C

3: water; sodium hydroxide / tetrahydrofuran / 0.5 h / 60 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl acetamide;
DOI:10.1248/cpb.59.215