8-{chloro(4-methoxyphenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol

Base Information

Chemical Name:8-{chloro(4-methoxyphenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol
CAS No.:1356187-69-3
Molecular Formula:C₂₃H₂₇ClO₅S
Molecular Weight:450.983
Hs Code.:

Synonyms:8-{chloro(4-methoxyphenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol

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Chemical Property of 8-{chloro(4-methoxyphenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol

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Technology Process of 8-{chloro(4-methoxyphenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol

There total 5 articles about 8-{chloro(4-methoxyphenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 4746-97-8
cyclohexanedione monoethylene ketal

: (chloro)(4-methoxyphenyl)methyl p-tolyl sulfoxide

: 1356187-69-3
8-{chloro(4-methoxyphenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol

Guidance literature:: (chloro)(4-methoxyphenyl)methyl p-tolyl sulfoxide; With lithium diisopropyl amide; In tetrahydrofuran; Inert atmosphere; Cooling;

cyclohexanedione monoethylene ketal; In tetrahydrofuran; Inert atmosphere; Cooling;
DOI:10.1055/s-0031-1260251

Reference yield:

: 5023-68-7
4-methoxybenzyl-(4'-methylphenyl)-sulfide

: 1356187-69-3
8-{chloro(4-methoxyphenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.5 h / 0 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

2.2: -78 - -30 °C / Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran / Inert atmosphere; Cooling

3.2: Inert atmosphere; Cooling

With 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; chloroform;
DOI:10.1055/s-0031-1260251

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1356187-69-3
8-{chloro(4-methoxyphenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium ethanolate / ethanol / 0.25 h / 0 °C

1.2: 0.25 h

2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.5 h / 0 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

3.2: -78 - -30 °C / Inert atmosphere

4.1: lithium diisopropyl amide / tetrahydrofuran / Inert atmosphere; Cooling

4.2: Inert atmosphere; Cooling

With sodium ethanolate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1055/s-0031-1260251