5'-O-tosyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine

Base Information

• Chemical Name: 5'-O-tosyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine
• CAS No.: 107201-96-7
• Molecular Formula: C₂₃H₃₃N₅O₅SSi
• Molecular Weight: 519.697
• Mol file: 107201-96-7.mol

Synonyms:5'-O-tosyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine

Chemical Property of 5'-O-tosyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 5'-O-tosyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine

There total 1 articles about 5'-O-tosyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine (51549-31-6) + p-toluenesulfonyl chloride (98-59-9) → 5'-O-tosyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine (107201-96-7)

Guidance literature:

With dmap; In dichloromethane; at 4 ℃; for 20h;

DOI:10.1021/jo00385a026

Reference yield: 73.0%

5'-O-tosyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine (107201-96-7) → 5′-O-toluenesulphonyl-2′-deoxyadenosine (6698-29-9)

Guidance literature:

With hydrogen fluoride; In acetonitrile; for 24h;

DOI:10.1021/jo00385a026

upstream raw materials:

3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine

p-toluenesulfonyl chloride

Downstream raw materials:

5′-O-toluenesulphonyl-2′-deoxyadenosine