6698-29-9Relevant articles and documents
Diadenosine 5',5'-(Boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors ⊥
Eliahu, Shay,Lecka, Joanna,Reiser, Georg,Haas, Michael,Bigonnesse, Fran?ois,Lévesque, Sébastien A.,Pelletier, Julie,Sévigny, Jean,Fischer, Bilha
, p. 8485 - 8497 (2010)
Nucleotide pyrophosphatase/phosphodiesterases (NPPs) hydrolyze extracellular nucleotides and dinucleotides and thus control purinergic signaling. Enhanced NPP activity is implicated in health disorders such as osteoarthritis and cancer. We designed novel
α,β-Difluoromethylene deoxynucleoside 5′-triphosphates: A convenient synthesis of useful probes for DNA polymerase β structure and function
Upton, Thomas G.,Kashemirov, Boris A.,McKenna, Charles E.,Goodman, Myron F.,Prakash, G. K. Surya,Kultyshev, Roman,Batra, Vinod K.,Shock, David D.,Pedersen, Lars C.,Beard, William A.,Wilson, Samuel H.
supporting information; experimental part, p. 1883 - 1886 (2009/10/10)
αβ-Difluoromethylene deoxynucleoside 5′-triphosphates (dNTPs, N = A or C) are advantageously obtained via phosphorylation of corresponding dNDP analogues using catalytic ATP, PEP, nucleoside diphosphate kinase, and pyruvate kinase. DNA pol β Kdd values for the α, β-CF2 and unmodified dNTPs, α, β-NH dUTP, and the α, β-CH2 analogues of dATP and dGTP are discussed in relation to the conformations of α, β-CF2 dTTP versus α, β-NH dUTP bound into the enzyme active site.2009 American Chemical Society.
Novel P1,P2-substituted phosphonate analogues of 2'-deoxyadenosine and 2'-deoxythymidine 5'-triphosphates
Blackburn,Langston
, p. 6425 - 6428 (2007/10/02)
P1,P2-Substituted methylene, fluoromethylene, and difluoromethylene analogues of the deoxynucleotides 2'-deoxyadenosine 5'-triphosphate and thymidine 5'-triphosphate have been prepared by reaction between the bisphosphonic acid and t
