[4-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-3-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)phenoxy]acetic acid

Base Information

Chemical Name:[4-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-3-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)phenoxy]acetic acid
CAS No.:1445778-73-3
Molecular Formula:C₃₂H₃₉ClN₄O₆
Molecular Weight:611.138
Hs Code.:

Synonyms:[4-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-3-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)phenoxy]acetic acid

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Chemical Property of [4-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-3-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)phenoxy]acetic acid

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Technology Process of [4-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-3-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)phenoxy]acetic acid

There total 8 articles about [4-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-3-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)phenoxy]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1445778-72-2
[4-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-3-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)phenoxy]acetic acid ethyl ester

: 1445778-73-3
[4-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-3-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)phenoxy]acetic acid

Guidance literature:: With methanol; sodium hydroxide; In water; at 20 ℃; for 12h;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1445778-73-3
[4-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-3-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)phenoxy]acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: trimethylaluminum / dichloromethane; toluene / 0.5 h / 20 °C / Inert atmosphere

2.2: 12 h / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 130 °C / Microwave irradiation

4.1: potassium hydroxide; water / ethanol / 1.5 h / 150 °C / Microwave irradiation

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

5.2: 60 h / 20 °C

6.1: aluminum (III) chloride; ethanethiol / dichloromethane / 12 h / 20 °C / Inert atmosphere

7.1: triethylamine; potassium carbonate / acetonitrile / 12 h / 20 °C

8.1: sodium hydroxide; methanol / water / 12 h / 20 °C

With methanol; aluminum (III) chloride; N-chloro-succinimide; water; trimethylaluminum; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; ethanethiol; potassium hydroxide; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 637022-63-0
4-chloro-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1445778-73-3
[4-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-3-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)phenoxy]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: trimethylaluminum / dichloromethane; toluene / 0.5 h / 20 °C / Inert atmosphere

1.2: 12 h / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 130 °C / Microwave irradiation

3.1: potassium hydroxide; water / ethanol / 1.5 h / 150 °C / Microwave irradiation

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

4.2: 60 h / 20 °C

5.1: aluminum (III) chloride; ethanethiol / dichloromethane / 12 h / 20 °C / Inert atmosphere

6.1: triethylamine; potassium carbonate / acetonitrile / 12 h / 20 °C

7.1: sodium hydroxide; methanol / water / 12 h / 20 °C

With methanol; aluminum (III) chloride; water; trimethylaluminum; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; ethanethiol; potassium hydroxide; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;