9-((3aR,4R,6R,6aR)-2,2-Dimethyl-6-phenethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine

Base Information

• Chemical Name: 9-((3aR,4R,6R,6aR)-2,2-Dimethyl-6-phenethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine
• CAS No.: 859731-95-6
• Molecular Formula: C₂₀H₂₃N₅O₃
• Molecular Weight: 381.434

Synonyms:9-((3aR,4R,6R,6aR)-2,2-Dimethyl-6-phenethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine

Chemical Property of 9-((3aR,4R,6R,6aR)-2,2-Dimethyl-6-phenethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-((3aR,4R,6R,6aR)-2,2-Dimethyl-6-phenethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine

There total 4 articles about 9-((3aR,4R,6R,6aR)-2,2-Dimethyl-6-phenethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-benzoyl-N-[9-(2,2-dimethyl-6-phenethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide (859731-93-4) → 9-((3aR,4R,6R,6aR)-2,2-Dimethyl-6-phenethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine (859731-95-6)

Guidance literature:

With methylhydrazine; In ethanol; at 55 ℃; for 12h;

DOI:10.1016/j.bmcl.2005.03.107

Reference yield:

N-benzoyl-N-[9-(2,2-dimethyl-6-styryl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide (595608-13-2) → 9-((3aR,4R,6R,6aR)-2,2-Dimethyl-6-phenethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine (859731-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethyl acetate / 4 h

2: 88 percent / CH₃NH-NH₂ / ethanol / 12 h / 55 °C

With hydrogen; methylhydrazine; palladium on activated charcoal; In ethanol; ethyl acetate;

DOI:10.1016/j.bmcl.2005.03.107

Reference yield:

benzyltriphenylphosphonium chloride (1100-88-5) → 9-((3aR,4R,6R,6aR)-2,2-Dimethyl-6-phenethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine (859731-95-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 46 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 3 h / 55 °C

2: H₂ / Pd/C / ethyl acetate / 4 h

3: 88 percent / CH₃NH-NH₂ / ethanol / 12 h / 55 °C

With hydrogen; sodium hexamethyldisilazane; methylhydrazine; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; 1: Wittig reaction;

DOI:10.1016/j.bmcl.2005.03.107

upstream raw materials:

N-benzoyl-N-[9-(2,2-dimethyl-6-phenethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

N-benzoyl-N-[9-(2,2-dimethyl-6-styryl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

benzyltriphenylphosphonium chloride

N⁶,N⁶-bis-benzoyl-2',3'-O-isopropylideneadenosine-5'-aldehyde

Downstream raw materials:

5'-desoxy-5'-benzyladenosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 859731-95-6 9-((3aR,4R,6R,6aR)-2,2-Dimethyl-6-phenethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send