N-(3-(4-bromophenyl)prop-2-ynyl)-4-methyl-N-((2-methyloxiran-2-yl)methyl)benzenesulfonamide

Base Information

Chemical Name:N-(3-(4-bromophenyl)prop-2-ynyl)-4-methyl-N-((2-methyloxiran-2-yl)methyl)benzenesulfonamide
CAS No.:1260522-68-6
Molecular Formula:C₂₀H₂₀BrNO₃S
Molecular Weight:434.354
Hs Code.:

Synonyms:N-(3-(4-bromophenyl)prop-2-ynyl)-4-methyl-N-((2-methyloxiran-2-yl)methyl)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-(4-bromophenyl)prop-2-ynyl)-4-methyl-N-((2-methyloxiran-2-yl)methyl)benzenesulfonamide

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Technology Process of N-(3-(4-bromophenyl)prop-2-ynyl)-4-methyl-N-((2-methyloxiran-2-yl)methyl)benzenesulfonamide

There total 3 articles about N-(3-(4-bromophenyl)prop-2-ynyl)-4-methyl-N-((2-methyloxiran-2-yl)methyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1260522-77-7
N-(3-(4-bromophenyl)prop-2-yn-1-yl)-4-methyl-N-(2-methylallyl)benzenesulfonamide

: 1260522-68-6
N-(3-(4-bromophenyl)prop-2-ynyl)-4-methyl-N-((2-methyloxiran-2-yl)methyl)benzenesulfonamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ja109362m

Reference yield:

: 132330-45-1
4-methyl-N-(2-methylallyl)-N-(prop-2-ynyl)benzenesulfonamide

: 1260522-68-6
N-(3-(4-bromophenyl)prop-2-ynyl)-4-methyl-N-((2-methyloxiran-2-yl)methyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 16 h / 50 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1: Sonogashira coupling;
DOI:10.1021/ja109362m

Reference yield:

: 55022-46-3
4-methyl-N-prop-2-ynylbenzenesulfonamide

: 1260522-68-6
N-(3-(4-bromophenyl)prop-2-ynyl)-4-methyl-N-((2-methyloxiran-2-yl)methyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 0 °C / Reflux

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 16 h / 50 °C / Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetone; 2: Sonogashira coupling;
DOI:10.1021/ja109362m