N-(3-(4-bromophenyl)prop-2-yn-1-yl)-4-methyl-N-(2-methylallyl)benzenesulfonamide

Base Information

Chemical Name:N-(3-(4-bromophenyl)prop-2-yn-1-yl)-4-methyl-N-(2-methylallyl)benzenesulfonamide
CAS No.:1260522-77-7
Molecular Formula:C₂₀H₂₀BrNO₂S
Molecular Weight:418.354
Hs Code.:

Synonyms:N-(3-(4-bromophenyl)prop-2-yn-1-yl)-4-methyl-N-(2-methylallyl)benzenesulfonamide

Suppliers and Price of N-(3-(4-bromophenyl)prop-2-yn-1-yl)-4-methyl-N-(2-methylallyl)benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-(4-bromophenyl)prop-2-yn-1-yl)-4-methyl-N-(2-methylallyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-(4-bromophenyl)prop-2-yn-1-yl)-4-methyl-N-(2-methylallyl)benzenesulfonamide

There total 5 articles about N-(3-(4-bromophenyl)prop-2-yn-1-yl)-4-methyl-N-(2-methylallyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 589-87-7
1,4-bromoiodobenzene

: 132330-45-1
4-methyl-N-(2-methylallyl)-N-(prop-2-ynyl)benzenesulfonamide

: 1260522-77-7
N-(3-(4-bromophenyl)prop-2-yn-1-yl)-4-methyl-N-(2-methylallyl)benzenesulfonamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 50 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ja109362m

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 55022-46-3
4-methyl-N-prop-2-ynylbenzenesulfonamide

: 920-46-7,26937-45-1
Methacryloyl chloride

: 1260522-77-7
N-(3-(4-bromophenyl)prop-2-yn-1-yl)-4-methyl-N-(2-methylallyl)benzenesulfonamide

: 1189377-77-2
1,2-bis(4-(pyridin-4-yl)phenyl)ethyne

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 6 h / 60 °C / Inert atmosphere

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / 80 °C / Inert atmosphere

4: ammonium acetate / dichloromethane; ethanol / 0.17 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; potassium acetate; potassium carbonate; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/asia.201700706

Reference yield:

: 55022-46-3
4-methyl-N-prop-2-ynylbenzenesulfonamide

: 1260522-77-7
N-(3-(4-bromophenyl)prop-2-yn-1-yl)-4-methyl-N-(2-methylallyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 0 °C / Reflux

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 16 h / 50 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In acetone; 2: Sonogashira coupling;
DOI:10.1021/ja109362m