(R)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide

Base Information

Chemical Name:(R)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide
CAS No.:581812-92-2
Molecular Formula:C₁₉H₁₈F₃NO₃
Molecular Weight:365.352
Hs Code.:

Synonyms:(R)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide

Suppliers and Price of (R)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide

Chemical Property:

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Technology Process of (R)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide

There total 4 articles about (R)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 51019-43-3
(R)-(-)-O-acetylmandelic acid

: 15996-84-6
1-(4-trifluoromethylphenyl)ethylamine

: 581812-92-2
(R)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide

: 581812-91-1
(S)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2007.04.105

Reference yield:

: (R)-(-)-O-acetylmandelic acid

: 15996-84-6
1-(4-trifluoromethylphenyl)ethylamine

: 581812-92-2
(R)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide

: 581812-91-1
(S)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; at 20 ℃;

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 581812-92-2
(R)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 16 h / 20 °C

2: H₂; NH₃ / Pd/C / methanol

3: 42 percent / DCC; DMAP / CH₂Cl₂ / 16 h / 20 °C

With pyridine; dmap; ammonia; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2007.04.105