7-bromo-5-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole

Base Information

Chemical Name:7-bromo-5-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole
CAS No.:1181566-79-9
Molecular Formula:C₂₈H₂₀BrF₂NO₂
Molecular Weight:520.373
Hs Code.:

Synonyms:7-bromo-5-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole

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Chemical Property of 7-bromo-5-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole

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Technology Process of 7-bromo-5-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole

There total 4 articles about 7-bromo-5-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1181566-78-8
7-bromo-5-fluoro-4-[(phenylmethyl)oxy]-1H-indole

: 133057-83-7
4-benzyloxy-3-fluorophenylboronic acid

: 1181566-79-9
7-bromo-5-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole

Guidance literature:: 7-bromo-5-fluoro-4-[(phenylmethyl)oxy]-1H-indole; 4-benzyloxy-3-fluorophenylboronic acid; With pyridine; oxygen; copper diacetate; In dichloromethane; for 20h; Molecular sieve;

4-benzyloxy-3-fluorophenylboronic acid; In dichloromethane; for 24h;

4-benzyloxy-3-fluorophenylboronic acid; With pyridine; copper diacetate; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 661463-12-3
4-bromo-2-fluoro-5-nitrophenol

: 1181566-79-9
7-bromo-5-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Sonication

2.1: tetrahydrofuran / -40 - -30 °C

3.1: pyridine; oxygen / copper diacetate / dichloromethane / 20 h / Molecular sieve

3.2: 24 h

3.3: 24 h / 20 °C

With pyridine; oxygen; caesium carbonate; copper diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 100-39-0
benzyl bromide

: 1181566-79-9
7-bromo-5-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Sonication

2.1: tetrahydrofuran / -40 - -30 °C

3.1: pyridine; oxygen / copper diacetate / dichloromethane / 20 h / Molecular sieve

3.2: 24 h

3.3: 24 h / 20 °C

With pyridine; oxygen; caesium carbonate; copper diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;