(1R,2S)-1-(4-trifluoromethylphenyl)-2-{2-[(S)-p-tolylsulfinyl]phenyl}propylamine

Base Information

Chemical Name:(1R,2S)-1-(4-trifluoromethylphenyl)-2-{2-[(S)-p-tolylsulfinyl]phenyl}propylamine
CAS No.:950829-39-7
Molecular Formula:C₂₃H₂₂F₃NOS
Molecular Weight:417.495
Hs Code.:

Synonyms:(1R,2S)-1-(4-trifluoromethylphenyl)-2-{2-[(S)-p-tolylsulfinyl]phenyl}propylamine

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Chemical Property of (1R,2S)-1-(4-trifluoromethylphenyl)-2-{2-[(S)-p-tolylsulfinyl]phenyl}propylamine

Chemical Property:

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Technology Process of (1R,2S)-1-(4-trifluoromethylphenyl)-2-{2-[(S)-p-tolylsulfinyl]phenyl}propylamine

There total 3 articles about (1R,2S)-1-(4-trifluoromethylphenyl)-2-{2-[(S)-p-tolylsulfinyl]phenyl}propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 950829-31-9
(1R,2S)-N-(2,4,6-trimethoxyphenyl)-1-(4-trifluoromethylphenyl)-2-{2-[(S)-p-tolylsulfinyl]phenyl}propylamine

: 950829-39-7
(1R,2S)-1-(4-trifluoromethylphenyl)-2-{2-[(S)-p-tolylsulfinyl]phenyl}propylamine

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetonitrile; for 2h;
DOI:10.1002/chem.200601893

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 950829-39-7
(1R,2S)-1-(4-trifluoromethylphenyl)-2-{2-[(S)-p-tolylsulfinyl]phenyl}propylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 48 percent / 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

2.1: nBuLi; iPr₂NH / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.2: 51 percent / hexane; tetrahydrofuran / -78 °C

3.1: 82 percent / CAN / H₂O; acetonitrile / 2 h

With n-butyllithium; ammonium cerium(IV) nitrate; 4 A molecular sieve; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; water; acetonitrile;
DOI:10.1002/chem.200601893

Reference yield:

: N-(2,4,6-trimethoxyphenyl)-4-trifluoromethylbenzylidenimine

: 950829-39-7
(1R,2S)-1-(4-trifluoromethylphenyl)-2-{2-[(S)-p-tolylsulfinyl]phenyl}propylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: nBuLi; iPr₂NH / hexane; tetrahydrofuran / 0.25 h / -78 °C

1.2: 51 percent / hexane; tetrahydrofuran / -78 °C

2.1: 82 percent / CAN / H₂O; acetonitrile / 2 h

With n-butyllithium; ammonium cerium(IV) nitrate; diisopropylamine; In tetrahydrofuran; hexane; water; acetonitrile;
DOI:10.1002/chem.200601893