1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-yn-1-ol

Base Information

Chemical Name:1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-yn-1-ol
CAS No.:934009-31-1
Molecular Formula:C₃₅H₄₀OSi
Molecular Weight:504.787
Hs Code.:

Synonyms:1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-yn-1-ol

Suppliers and Price of 1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-yn-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-yn-1-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-yn-1-ol

There total 7 articles about 1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 93319-68-7
1,1'-(2-ethynylcyclopropane-1,1-diyl)dibenzene

: 396717-20-7
2-[(triisopropylsilanyl)-ethynyl]-benzaldehyde

: 934009-31-1
1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-yn-1-ol

Guidance literature:: 1,1'-(2-ethynylcyclopropane-1,1-diyl)dibenzene; With ethylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 4h;

2-[(triisopropylsilanyl)-ethynyl]-benzaldehyde; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/jo062448+

Reference yield:

: 934009-26-4
[2-(2,2-dibromovinyl)-1-phenylcyclopropyl]benzene

: 934009-31-1
1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / n-butyllithium / tetrahydrofuran; hexane / 3 h / -78 - 20 °C

2.1: ethyl magnesium bromide / tetrahydrofuran / 4 h / 20 °C

2.2: 98 percent / tetrahydrofuran / 12 h / 20 °C

With n-butyllithium; ethylmagnesium bromide; In tetrahydrofuran; hexane;
DOI:10.1021/jo062448+

Reference yield:

: 530-48-3
1,1-Diphenylethylene

: 934009-31-1
1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-yn-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper acetoacetate / 1,2-dichloro-ethane / 15 h / 20 °C

2.1: 3.15 g / potassium hydroxide / H₂O; methanol / 12 h / 20 °C

3.1: 28 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 - 20 °C

4.1: 85 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / 20 °C

5.1: triphenylphosphine; zinc / CH₂Cl₂ / 20 h / 20 °C

5.2: 93 percent / CH₂Cl₂ / 20 h / 20 °C

6.1: 89 percent / n-butyllithium / tetrahydrofuran; hexane / 3 h / -78 - 20 °C

7.1: ethyl magnesium bromide / tetrahydrofuran / 4 h / 20 °C

7.2: 98 percent / tetrahydrofuran / 12 h / 20 °C

With potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; copper acetyl-acetate; ethylmagnesium bromide; triphenylphosphine; pyridinium chlorochromate; zinc; In tetrahydrofuran; methanol; hexane; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1021/jo062448+