1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-ynyl acetate

Base Information

Chemical Name:1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-ynyl acetate
CAS No.:934009-16-2
Molecular Formula:C₃₇H₄₂O₂Si
Molecular Weight:546.825
Hs Code.:

Synonyms:1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-ynyl acetate

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Chemical Property of 1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-ynyl acetate

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Technology Process of 1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-ynyl acetate

There total 8 articles about 1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-ynyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 934009-31-1
1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-yn-1-ol

: 108-24-7
acetic anhydride

: 934009-16-2
1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-ynyl acetate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jo062448+

Reference yield:

: 934009-26-4
[2-(2,2-dibromovinyl)-1-phenylcyclopropyl]benzene

: 934009-16-2
1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-ynyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 89 percent / n-butyllithium / tetrahydrofuran; hexane / 3 h / -78 - 20 °C

2.1: ethyl magnesium bromide / tetrahydrofuran / 4 h / 20 °C

2.2: 98 percent / tetrahydrofuran / 12 h / 20 °C

3.1: 95 percent / 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂ / 2 h / 20 °C

With dmap; n-butyllithium; ethylmagnesium bromide; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo062448+

Reference yield:

: 530-48-3
1,1-Diphenylethylene

: 934009-16-2
1-{2-[2-(triisopropylsilyl)ethynyl]phenyl}-3-(2,2-diphenylcyclopropyl)prop-2-ynyl acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: copper acetoacetate / 1,2-dichloro-ethane / 15 h / 20 °C

2.1: 3.15 g / potassium hydroxide / H₂O; methanol / 12 h / 20 °C

3.1: 28 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 - 20 °C

4.1: 85 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / 20 °C

5.1: triphenylphosphine; zinc / CH₂Cl₂ / 20 h / 20 °C

5.2: 93 percent / CH₂Cl₂ / 20 h / 20 °C

6.1: 89 percent / n-butyllithium / tetrahydrofuran; hexane / 3 h / -78 - 20 °C

7.1: ethyl magnesium bromide / tetrahydrofuran / 4 h / 20 °C

7.2: 98 percent / tetrahydrofuran / 12 h / 20 °C

8.1: 95 percent / 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂ / 2 h / 20 °C

With dmap; potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; copper acetyl-acetate; ethylmagnesium bromide; triethylamine; triphenylphosphine; pyridinium chlorochromate; zinc; In tetrahydrofuran; methanol; hexane; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1021/jo062448+