2-(2-methoxy-phenyl)-benzooxazole-7-carboxylic acid methyl ester

Base Information

• Chemical Name: 2-(2-methoxy-phenyl)-benzooxazole-7-carboxylic acid methyl ester
• CAS No.: 908371-40-4
• Molecular Formula: C₁₆H₁₃NO₄
• Molecular Weight: 283.284
• Mol file: 908371-40-4.mol

Synonyms:2-(2-methoxy-phenyl)-benzooxazole-7-carboxylic acid methyl ester

Chemical Property of 2-(2-methoxy-phenyl)-benzooxazole-7-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(2-methoxy-phenyl)-benzooxazole-7-carboxylic acid methyl ester

There total 4 articles about 2-(2-methoxy-phenyl)-benzooxazole-7-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

2-hydroxy-3-(2-methoxybenzoylamino)benzoic acid methyl ester (908371-39-1) → methyl 2-(2-hydroxy-phenyl)-benzooxazole-7-carboxylate + 2-(2-methoxy-phenyl)-benzooxazole-7-carboxylic acid methyl ester (908371-40-4)

Guidance literature:

With toluene-4-sulfonic acid; In xylene; for 96h; Heating;

DOI:10.1016/j.bmc.2006.05.007

Reference yield:

2-methoxybenzoic acid methyl ester (606-45-1) → 2-(2-methoxy-phenyl)-benzooxazole-7-carboxylic acid methyl ester (908371-40-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 56 percent / sodium hydroxide / methanol / 3 h / Heating

2: oxalyl chloride; N,N-dimethylformamide / CH₂Cl₂ / 2 h / 20 °C

3: 0.20 g / pyridine / CH₂Cl₂

4: 32 percent / p-toluenesulfonic acid / xylene / 96 h / Heating

With pyridine; sodium hydroxide; oxalyl dichloride; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In methanol; dichloromethane; xylene;

DOI:10.1016/j.bmc.2006.05.007

Reference yield:

2-Methoxybenzoic acid (579-75-9) → 2-(2-methoxy-phenyl)-benzooxazole-7-carboxylic acid methyl ester (908371-40-4)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl chloride; N,N-dimethylformamide / CH₂Cl₂ / 2 h / 20 °C

2: 0.20 g / pyridine / CH₂Cl₂

3: 32 percent / p-toluenesulfonic acid / xylene / 96 h / Heating

With pyridine; oxalyl dichloride; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In dichloromethane; xylene;

DOI:10.1016/j.bmc.2006.05.007

upstream raw materials:

2-hydroxy-3-(2-methoxybenzoylamino)benzoic acid methyl ester

2-methoxybenzoic acid methyl ester

2-Methoxybenzoic acid

2-Methoxybenzoyl chloride

Downstream raw materials:

2-hydroxy-3-{[2-(2-methoxyphenyl)benzoxazole-7-carbonyl]amino}benzoic acid methyl ester

2-(2-methoxy-phenyl)-benzooxazole-7-carboxylic acid