{4-[4-chloro-2-(4-chlorophenylsulfanyl)benzenesulfinyl]phenyl} dimethylamine

Base Information

• Chemical Name: {4-[4-chloro-2-(4-chlorophenylsulfanyl)benzenesulfinyl]phenyl} dimethylamine
• CAS No.: 1044573-06-9
• Molecular Formula: C₂₀H₁₇ClFNOS₂
• Molecular Weight: 405.944
• Mol file: 1044573-06-9.mol

Synonyms:{4-[4-chloro-2-(4-chlorophenylsulfanyl)benzenesulfinyl]phenyl} dimethylamine

Chemical Property of {4-[4-chloro-2-(4-chlorophenylsulfanyl)benzenesulfinyl]phenyl} dimethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {4-[4-chloro-2-(4-chlorophenylsulfanyl)benzenesulfinyl]phenyl} dimethylamine

There total 3 articles about {4-[4-chloro-2-(4-chlorophenylsulfanyl)benzenesulfinyl]phenyl} dimethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

[4-(4-fluoro-benzenesulfinyl)-phenyl]dimethylamine (90309-29-8) + S-(4-chlorophenyl)benzene thiosulfonate (1213-40-7) → {4-[4-chloro-2-(4-chlorophenylsulfanyl)benzenesulfinyl]phenyl} dimethylamine (1044573-06-9)

Guidance literature:

[4-(4-fluoro-benzenesulfinyl)-phenyl]dimethylamine; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at -30 ℃; Inert atmosphere;

S-(4-chlorophenyl)benzene thiosulfonate; In tetrahydrofuran; at 25 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol801431z

Reference yield:

4-(dimethylamino)benzenethiocyanate (7152-80-9) → {4-[4-chloro-2-(4-chlorophenylsulfanyl)benzenesulfinyl]phenyl} dimethylamine (1044573-06-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrahydrofuran / -20 - 25 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / -20 °C / Inert atmosphere

3.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / -30 °C / Inert atmosphere

3.2: 1 h / 25 °C / Inert atmosphere

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water;

DOI:10.1002/chem.201003657

Reference yield:

4-((4-fluorophenyl)thio)-N,N-dimethylaniline (68253-25-8) → {4-[4-chloro-2-(4-chlorophenylsulfanyl)benzenesulfinyl]phenyl} dimethylamine (1044573-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / -20 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / -30 °C / Inert atmosphere

2.2: 1 h / 25 °C / Inert atmosphere

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water;

DOI:10.1002/chem.201003657

upstream raw materials:

[4-(4-fluoro-benzenesulfinyl)-phenyl]dimethylamine

S-(4-chlorophenyl)benzene thiosulfonate

4-(dimethylamino)benzenethiocyanate

4-((4-fluorophenyl)thio)-N,N-dimethylaniline

Downstream raw materials:

1-(2-((4-chlorophenyl)thio)-4-fluorophenyl)-N,N-dimethylmethanamine