tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate

Base Information

Chemical Name:tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate
CAS No.:111216-46-7
Molecular Formula:C₃₇H₃₆N₂O₇
Molecular Weight:620.702
Hs Code.:

tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-<p-(benzyloxy)phenyl>glycinate

Synonyms:tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate

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Chemical Property of tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate

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Technology Process of tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate

There total 1 articles about tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 123004-72-8
D-glycine tert-butyl ester toluenesulfonate salt

: L-Ox-serine dicyclohexylammonium salt

: 111216-46-7
tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; 1.) 0 deg C, 2.5 h, 2.) RT, 1.5 h;
DOI:10.1021/ja00158a040

Reference yield: 96.0%

: 111216-46-7
tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate

: 110207-46-0
(-)-3-N-(4,5-diphenyl-4-oxazolin-2-onyl)aminocardicinic acid tert-butyl ester

Guidance literature:: With diethylazodicarboxylate; triethyl phosphite; In tetrahydrofuran; at 20 ℃; for 12h; Darkness;
DOI:10.1021/jo4007893

Reference yield:

: 111216-46-7
tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate

: 65309-11-7
(-)-nocardicin G

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent

2: 94 percent / H₂,HCl / 10percent Pd/C / 48 h / 2585.7 Torr

3: 59 percent / i-BuOCOCl/2,6-lutidine / acetone; dimethylformamide / 1.5 h / -5 - 20 °C

4: 90 percent / TFA / various solvent(s) / 1 h / 0 - 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; hydrogen; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(00)83888-5