(S)-8-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

Base Information

Chemical Name:(S)-8-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide
CAS No.:1398717-87-7
Molecular Formula:C₃₀H₃₉N₅O₃
Molecular Weight:517.671
Hs Code.:

Synonyms:(S)-8-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

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Chemical Property of (S)-8-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

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Technology Process of (S)-8-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

There total 16 articles about (S)-8-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1398718-50-7
(S)-(9H-fluoren-9-yl)methyl 8-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-1,4-dioxaspiro[4.5]decan-8-ylcarbamate

: 1398717-87-7
(S)-8-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

Guidance literature:: With piperidine; In dichloromethane; at 20 ℃;

Reference yield:

: 24250-84-8
H-p-BrPhe-OH

: 1398717-87-7
(S)-8-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / Reflux

2.1: sodium hydrogencarbonate / acetone / 20 °C

3.1: ammonia; methanol / 0.25 h / -50 - 20 °C

4.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

5.1: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide; water / 3 h / 100 °C

6.1: formic acid / 4 h / 40 °C

7.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / dichloromethane / 0.5 h / 0 °C

7.2: 12 h / 20 °C

8.1: piperidine / dichloromethane / 20 °C

With piperidine; methanol; formic acid; thionyl chloride; ammonia; sodium hydrogencarbonate; sodium carbonate; triethylamine; trifluoroacetic anhydride; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 1398717-87-7
(S)-8-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: sodium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

3.1: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide; water / 3 h / 100 °C

4.1: formic acid / 4 h / 40 °C

5.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / dichloromethane / 0.5 h / 0 °C

5.2: 12 h / 20 °C

6.1: piperidine / dichloromethane / 20 °C

With piperidine; formic acid; sodium acetate; sodium carbonate; potassium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;