(S)-(9H-fluoren-9-yl)methyl 8-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-1,4-dioxaspiro[4.5]decan-8-ylcarbamate

Base Information

Chemical Name:(S)-(9H-fluoren-9-yl)methyl 8-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-1,4-dioxaspiro[4.5]decan-8-ylcarbamate
CAS No.:1398718-50-7
Molecular Formula:C₄₅H₄₉N₅O₅
Molecular Weight:739.915
Hs Code.:

Synonyms:(S)-(9H-fluoren-9-yl)methyl 8-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-1,4-dioxaspiro[4.5]decan-8-ylcarbamate

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Chemical Property of (S)-(9H-fluoren-9-yl)methyl 8-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-1,4-dioxaspiro[4.5]decan-8-ylcarbamate

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Technology Process of (S)-(9H-fluoren-9-yl)methyl 8-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-1,4-dioxaspiro[4.5]decan-8-ylcarbamate

There total 15 articles about (S)-(9H-fluoren-9-yl)methyl 8-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-1,4-dioxaspiro[4.5]decan-8-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1398718-28-9
(S)-2-amino-3-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)propanenitrile

: 369403-24-7
8-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1,4-dioxaspiro[4,5]decane-8-carboxylic acid

: 1398718-50-7
(S)-(9H-fluoren-9-yl)methyl 8-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-1,4-dioxaspiro[4.5]decan-8-ylcarbamate

Guidance literature:: (S)-2-amino-3-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)propanenitrile; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In dichloromethane; at 0 ℃; for 0.5h;

8-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1,4-dioxaspiro[4,5]decane-8-carboxylic acid; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 24250-84-8
H-p-BrPhe-OH

: 1398718-50-7
(S)-(9H-fluoren-9-yl)methyl 8-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-1,4-dioxaspiro[4.5]decan-8-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / Reflux

2.1: sodium hydrogencarbonate / acetone / 20 °C

3.1: ammonia; methanol / 0.25 h / -50 - 20 °C

4.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

5.1: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide; water / 3 h / 100 °C

6.1: formic acid / 4 h / 40 °C

7.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / dichloromethane / 0.5 h / 0 °C

7.2: 12 h / 20 °C

With methanol; formic acid; thionyl chloride; ammonia; sodium hydrogencarbonate; sodium carbonate; triethylamine; trifluoroacetic anhydride; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 1398718-50-7
(S)-(9H-fluoren-9-yl)methyl 8-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-1,4-dioxaspiro[4.5]decan-8-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: sodium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

3.1: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide; water / 3 h / 100 °C

4.1: formic acid / 4 h / 40 °C

5.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / dichloromethane / 0.5 h / 0 °C

5.2: 12 h / 20 °C

With formic acid; sodium acetate; sodium carbonate; potassium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;