4-[(3-chlorophenyl)oxy]-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine

Base Information

Chemical Name:4-[(3-chlorophenyl)oxy]-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine
CAS No.:925979-09-5
Molecular Formula:C₁₉H₁₈ClN₃O₃
Molecular Weight:371.823
Hs Code.:

Synonyms:4-[(3-chlorophenyl)oxy]-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine

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Chemical Property of 4-[(3-chlorophenyl)oxy]-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine

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Technology Process of 4-[(3-chlorophenyl)oxy]-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine

There total 8 articles about 4-[(3-chlorophenyl)oxy]-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871819-61-3
4-chloro-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine

: 108-43-0
3-monochlorophenol

: 925979-09-5
4-[(3-chlorophenyl)oxy]-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: 3-monochlorophenol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

4-chloro-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine; In N,N-dimethyl-formamide; at 180 ℃; for 4h; Microwave;

Reference yield:

: 871819-39-5
2-methoxycarbonylmethyl-1-methyl-1H-pyrrole-3-carboxylic acid methyl ester

: 925979-09-5
4-[(3-chlorophenyl)oxy]-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 20 °C

2.1: ammonium acetate / methanol / 2 h / Heating / reflux

3.1: sodium t-butanolate / N,N-dimethyl-formamide / 0.08 h / 160 °C / Microwave

4.1: O-phenyl phosphorodichloridate / 0.5 h / 180 °C

5.1: sodium hydroxide; water / methanol / 4 h / Heating / reflux

5.2: pH 1

6.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 °C

7.2: 4 h / 180 °C / Microwave

With N-ethylmorpholine;; sodium hydroxide; ammonium acetate; water; sodium hydride; benzotriazol-1-ol; O-phenyl phosphorodichloridate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium t-butanolate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 871819-60-2
4-chloro-1-methyl-1H-pyrrolo[3,2-c]pyridine-7-carboxylic acid

: 925979-09-5
4-[(3-chlorophenyl)oxy]-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 °C

2.2: 4 h / 180 °C / Microwave

With N-ethylmorpholine;; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;