Technology Process of 1H-Pyrrole-2-acetic acid, 3-(methoxycarbonyl)-1-methyl-, methyl ester
There total 2 articles about 1H-Pyrrole-2-acetic acid, 3-(methoxycarbonyl)-1-methyl-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
methanol;
for 48h;
Reflux;
Inert atmosphere;
DOI:10.1021/jm9009857
- Guidance literature:
-
Multi-step reaction with 2 steps
1: water / 17 h / 10 - 20 °C
2: toluene-4-sulfonic acid / 44 - 48 h / Heating / reflux
With
toluene-4-sulfonic acid;
In
water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / tetrahydrofuran / 20 °C
2.1: ammonium acetate / methanol / 2 h / Heating / reflux
3.1: sodium t-butanolate / N,N-dimethyl-formamide / 0.08 h / 160 °C / Microwave
4.1: O-phenyl phosphorodichloridate / 0.5 h / 180 °C
5.1: sodium hydroxide; water / methanol / 4 h / Heating / reflux
5.2: pH 1
6.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C
7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 20 - 80 °C
With
N-ethylmorpholine;; sodium hydroxide; ammonium acetate; water; sodium hydride; sodium carbonate; benzotriazol-1-ol; O-phenyl phosphorodichloridate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium t-butanolate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
7.1: Suzuki Coupling;
