5-benzyloxy-4-methoxy-2-(methoxymethoxymethyl)phenylboronic acid

Base Information

• Chemical Name: 5-benzyloxy-4-methoxy-2-(methoxymethoxymethyl)phenylboronic acid
• CAS No.: 937167-97-0
• Molecular Formula: C₁₇H₂₁BO₆
• Molecular Weight: 332.161
• Mol file: 937167-97-0.mol

Synonyms:5-benzyloxy-4-methoxy-2-(methoxymethoxymethyl)phenylboronic acid

Chemical Property of 5-benzyloxy-4-methoxy-2-(methoxymethoxymethyl)phenylboronic acid

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-benzyloxy-4-methoxy-2-(methoxymethoxymethyl)phenylboronic acid

There total 3 articles about 5-benzyloxy-4-methoxy-2-(methoxymethoxymethyl)phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H19O4BH2O2(C3H6)2 → 5-benzyloxy-4-methoxy-2-(methoxymethoxymethyl)phenylboronic acid (937167-97-0)

Guidance literature:

With water; In tetrahydrofuran; hexane; at 20 ℃;

DOI:10.1021/jo062592v

Reference yield:

4-benzyloxy-2-iodo-5-methoxy-1-(methoxymethoxymethyl)benzene (937167-94-7) → 5-benzyloxy-4-methoxy-2-(methoxymethoxymethyl)phenylboronic acid (937167-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

2: H₂O / tetrahydrofuran; hexane / 20 °C

With n-butyllithium; water; In tetrahydrofuran; hexane;

DOI:10.1021/jo062592v

Reference yield:

(4-benzyloxy-2-iodo-5-methoxyphenyl)methanol (169137-67-1) → 5-benzyloxy-4-methoxy-2-(methoxymethoxymethyl)phenylboronic acid (937167-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / NaH / tetrahydrofuran / 5 h / 20 - 60 °C

2: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

3: H₂O / tetrahydrofuran; hexane / 20 °C

With n-butyllithium; water; sodium hydride; In tetrahydrofuran; hexane;

DOI:10.1021/jo062592v

upstream raw materials:

4-benzyloxy-2-iodo-5-methoxy-1-(methoxymethoxymethyl)benzene

(4-benzyloxy-2-iodo-5-methoxyphenyl)methanol

Downstream raw materials:

3-[5'-benzyloxy-4'-methoxy-2'-(methoxymethoxymethyl)phenyl]-4-hydroxy-5,6,7-trimethoxychromen-2-one

3-[5'-benzyloxy-4'-methoxy-2'-(methoxymethoxymethyl)phenyl]-4-hydroxy-5,7-dimethoxychromen-2-one

3-[5'-benzyloxy-4'-methoxy-2'-(methoxymethoxymethyl)phenyl]-4-hydroxy-6,7-dimethoxychromen-2-one