3-(4-(tert-butyl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one

Base Information

• Chemical Name: 3-(4-(tert-butyl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one
• CAS No.: 1354694-46-4
• Molecular Formula: C₁₉H₂₁NO
• Molecular Weight: 279.382
• Mol file: 1354694-46-4.mol

Synonyms:3-(4-(tert-butyl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one

Chemical Property of 3-(4-(tert-butyl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-(4-(tert-butyl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one

There total 3 articles about 3-(4-(tert-butyl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-tert-Butylstyrene (1746-23-2,26009-55-2) + N-methoxybenzamide (2446-51-7) → 3-(4-(tert-butyl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one (1354694-46-4)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; sodium acetate; In 2,2,2-trifluoroethanol; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol2032575

Reference yield: 75.0%

4-tert-Butylstyrene (1746-23-2,26009-55-2) + N-((tert-butoxycarbonyl)oxy)benzamide (1293990-69-8) → 3-(4-(tert-butyl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one (1354694-46-4) + 3-(4-(tert-butyl)benzyl)isoindolin-1-one

Guidance literature:

With Cp*Rh(OBz)₂; In 2,2,2-trifluoroethanol; at 23 ℃; for 14h;

DOI:10.1002/chem.202001781

Reference yield: 68.0%

4-tert-Butylstyrene (1746-23-2,26009-55-2) + N-((tert-butoxycarbonyl)oxy)benzamide (1293990-69-8) → 3-(4-(tert-butyl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one (1354694-46-4)

Guidance literature:

N-((tert-butoxycarbonyl)oxy)benzamide; With C₁₃H₂₀Rh; dibenzoyl peroxide; In dichloromethane; at 23 ℃; for 0.0833333h; Inert atmosphere;

4-tert-Butylstyrene; In dichloromethane; at 23 ℃; for 14h; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201404515

upstream raw materials:

4-tert-Butylstyrene

N-methoxybenzamide

N-((tert-butoxycarbonyl)oxy)benzamide