N-(3-(((2S,4R)-4-((4-(thiophene-2-carboximidamido)phenoxy)methyl)pyrrolidin-2-yl)oxy)phenyl)thiophene-2-carboximidamide

Base Information

Chemical Name:N-(3-(((2S,4R)-4-((4-(thiophene-2-carboximidamido)phenoxy)methyl)pyrrolidin-2-yl)oxy)phenyl)thiophene-2-carboximidamide
CAS No.:1572937-15-5
Molecular Formula:C₂₇H₂₇N₅O₂S₂
Molecular Weight:517.676
Hs Code.:

Synonyms:N-(3-(((2S,4R)-4-((4-(thiophene-2-carboximidamido)phenoxy)methyl)pyrrolidin-2-yl)oxy)phenyl)thiophene-2-carboximidamide

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Chemical Property of N-(3-(((2S,4R)-4-((4-(thiophene-2-carboximidamido)phenoxy)methyl)pyrrolidin-2-yl)oxy)phenyl)thiophene-2-carboximidamide

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Technology Process of N-(3-(((2S,4R)-4-((4-(thiophene-2-carboximidamido)phenoxy)methyl)pyrrolidin-2-yl)oxy)phenyl)thiophene-2-carboximidamide

There total 8 articles about N-(3-(((2S,4R)-4-((4-(thiophene-2-carboximidamido)phenoxy)methyl)pyrrolidin-2-yl)oxy)phenyl)thiophene-2-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1572937-39-3
(2S,4R)-tert-butyl 4-(3-(thiophene-2-carboximidamido)phenoxy)-2-((4-(thiophene-2-carboximidamido)phenoxy)methyl)pyrrolidine-1-carboxylate

: 1572937-15-5
N-(3-(((2S,4R)-4-((4-(thiophene-2-carboximidamido)phenoxy)methyl)pyrrolidin-2-yl)oxy)phenyl)thiophene-2-carboximidamide

Guidance literature:: With hydrogenchloride; In methanol;

Reference yield:

: 74844-91-0,114676-69-6,135042-17-0,227935-38-8,102195-79-9
(2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester

: 1572937-15-5
N-(3-(((2S,4R)-4-((4-(thiophene-2-carboximidamido)phenoxy)methyl)pyrrolidin-2-yl)oxy)phenyl)thiophene-2-carboximidamide

Guidance literature:: Multi-step reaction with 6 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran

2: lithium borohydride / tetrahydrofuran

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran

4: hydrazine hydrate / methanol

5: ethanol / 24 h

6: hydrogenchloride / methanol

With hydrogenchloride; lithium borohydride; di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; 1: |Mitsunobu Displacement / 3: |Mitsunobu Displacement;

Reference yield:

: 20300-02-1
thiophene-2-carbothioamide

: 1572937-15-5
N-(3-(((2S,4R)-4-((4-(thiophene-2-carboximidamido)phenoxy)methyl)pyrrolidin-2-yl)oxy)phenyl)thiophene-2-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetone

2: ethanol / 24 h

3: hydrogenchloride / methanol

With hydrogenchloride; In methanol; ethanol; acetone;