Technology Process of (2R,3S)-5-methoxy-2'-oxo-1-(phenylsulfonyl)spiro[indoline-3,4'-oxazolidine]-2-yl methyl terephthalate
There total 6 articles about (2R,3S)-5-methoxy-2'-oxo-1-(phenylsulfonyl)spiro[indoline-3,4'-oxazolidine]-2-yl methyl terephthalate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,6-dimethylpyridine; (4S,4'S,5R,5'R)-2,2'-(propane-2,2-diyl)bis(4,5-diphenyl-4,5-dihydrooxazole); iron(II) acetate;
In
toluene; acetonitrile;
at 20 ℃;
for 1h;
stereoselective reaction;
Molecular sieve;
Inert atmosphere;
DOI:10.1021/ol401666e
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylamine / tetrahydrofuran / 1 h / 0 °C
2: 2,6-dimethylpyridine; iron(II) acetate; (4S,4'S,5R,5'R)-2,2'-(propane-2,2-diyl)bis(4,5-diphenyl-4,5-dihydrooxazole) / acetonitrile; toluene / 1 h / 20 °C / Molecular sieve; Inert atmosphere
With
2,6-dimethylpyridine; (4S,4'S,5R,5'R)-2,2'-(propane-2,2-diyl)bis(4,5-diphenyl-4,5-dihydrooxazole); iron(II) acetate; triethylamine;
In
tetrahydrofuran; toluene; acetonitrile;
DOI:10.1021/ol401666e
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 0.5 h / 0 °C
1.2: 0.5 h / 20 °C
2.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C
3.1: acetonitrile / 1 h / 20 °C
3.2: 4 h / 20 °C
4.1: triethylamine / tetrahydrofuran / 1 h / 0 °C
5.1: 2,6-dimethylpyridine; iron(II) acetate; (4S,4'S,5R,5'R)-2,2'-(propane-2,2-diyl)bis(4,5-diphenyl-4,5-dihydrooxazole) / acetonitrile; toluene / 1 h / 20 °C / Molecular sieve; Inert atmosphere
With
2,6-dimethylpyridine; sodium tetrahydroborate; (4S,4'S,5R,5'R)-2,2'-(propane-2,2-diyl)bis(4,5-diphenyl-4,5-dihydrooxazole); tetra(n-butyl)ammonium hydrogensulfate; iron(II) acetate; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/ol401666e
