Technology Process of (1'R,2R)-2-(1',2'-bis-benzyloxyethyl)-5-methoxy-tetrahydrofuran
There total 4 articles about (1'R,2R)-2-(1',2'-bis-benzyloxyethyl)-5-methoxy-tetrahydrofuran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetra-(n-butyl)ammonium iodide; sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 2h;
DOI:10.1021/ol0508126
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 90 percent / NaIO4 / OsO4 / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 2.5 h / 20 °C
2: 74 percent / d-camphorsulfonic acid / methanol / 18 h / 0 °C
3: 96 percent / n-tetrabutylammonium iodide; sodium hydride / dimethylformamide / 2 h / 0 - 20 °C
With
sodium periodate; (1S)-10-camphorsulfonic acid; tetra-(n-butyl)ammonium iodide; sodium hydride;
osmium(VIII) oxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
1: Lemieux-Johnson oxidation;
DOI:10.1021/ol0508126
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: CuBr / diethyl ether / 0.25 h / 0 °C
1.2: 11.2 g / diethyl ether / 2.5 h / 0 °C
2.1: 90 percent / NaIO4 / OsO4 / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 2.5 h / 20 °C
3.1: 74 percent / d-camphorsulfonic acid / methanol / 18 h / 0 °C
4.1: 96 percent / n-tetrabutylammonium iodide; sodium hydride / dimethylformamide / 2 h / 0 - 20 °C
With
sodium periodate; (1S)-10-camphorsulfonic acid; tetra-(n-butyl)ammonium iodide; sodium hydride; copper(I) bromide;
osmium(VIII) oxide;
In
tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; tert-butyl alcohol;
2.1: Lemieux-Johnson oxidation;
DOI:10.1021/ol0508126
