2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-3-methoxy-5-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopent-2-enone

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Chemical Name:2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-3-methoxy-5-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopent-2-enone
CAS No.:1262512-52-6
Molecular Formula:C₂₂H₂₂ClNO₃S
Molecular Weight:415.941
Hs Code.:

Synonyms:2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-3-methoxy-5-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopent-2-enone

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Chemical Property of 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-3-methoxy-5-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopent-2-enone

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Technology Process of 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-3-methoxy-5-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopent-2-enone

There total 6 articles about 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-3-methoxy-5-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopent-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50675-18-8
3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

: 1262512-50-4
2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-3-methoxy-cyclopent-2-enone

: 1262512-52-6
2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-3-methoxy-5-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopent-2-enone

Guidance literature:: 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-3-methoxy-cyclopent-2-enone; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 0.583333h; Inert atmosphere;

3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 - 20 ℃;

With potassium tert-butylate; In tetrahydrofuran; n-heptane; ethylbenzene; for 1.5h;

Reference yield:

: 2521-24-6
4-chlorothiobenzamide

: 1262512-52-6
2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-3-methoxy-5-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopent-2-enone

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium carbonate hexahydrate / 1,2-dimethoxyethane / 3 h / 60 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

2.2: 0.08 h

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.1: 1-butyl-3-methylimidazolium trifluoromethanesulfonimide / 1,2-dimethoxyethane / 0.5 h / 230 °C / microwave irradiation

5.1: potassium carbonate / acetone / 6 h / 40 °C

6.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.58 h / -78 °C / Inert atmosphere

6.2: -78 - 20 °C

6.3: 1.5 h

With sodium tetrahydroborate; magnesium carbonate hexahydrate; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; 1-butyl-3-methylimidazolium trifluoromethanesulfonimide; lithium diisopropyl amide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; n-heptane; ethylbenzene; acetone;

Reference yield:

: 721920-84-9
2-(4-chloro-phenyl)-thiazole-5-carbaldehyde

: 1262512-52-6
2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-3-methoxy-5-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopent-2-enone

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

1.2: 0.08 h

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: 1-butyl-3-methylimidazolium trifluoromethanesulfonimide / 1,2-dimethoxyethane / 0.5 h / 230 °C / microwave irradiation

4.1: potassium carbonate / acetone / 6 h / 40 °C

5.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.58 h / -78 °C / Inert atmosphere

5.2: -78 - 20 °C

5.3: 1.5 h

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; 1-butyl-3-methylimidazolium trifluoromethanesulfonimide; lithium diisopropyl amide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; n-heptane; ethylbenzene; acetone;