721920-84-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Chlorophenyl)thiazole-5-carbaldehyde is used as a key intermediate in the synthesis of various bioactive molecules for pharmaceutical applications. Its heterocyclic structure allows for the development of new drugs with potential therapeutic effects.
Used in Chemical Research:
In the field of chemical research, 2-(4-Chlorophenyl)thiazole-5-carbaldehyde serves as a valuable compound for studying the properties and reactivity of heterocyclic structures. This understanding can lead to the discovery of new chemical reactions and the synthesis of novel compounds with potential applications in various industries.

InChI:InChI=1/C10H6ClNOS/c11-8-3-1-7(2-4-8)10-12-5-9(6-13)14-10/h1-6H

Upstream product

• 2065-75-0 2-Bromo-malonaldehyde 
• 2521-24-6 4-chlorothiobenzamide 
• 464192-28-7 2-bromo-1,3-thiazole-5-carbaldehyde 
• 1679-18-1 4-Chlorophenylboronic acid 
• 36437-19-1 2-chloromalonaldehyde 

Downstream Products

• 1369465-55-3 C₁₂H₈ClNO₂S 
• 1094621-85-8 1-[2-(4-chloro-phenyl)-thiazol-5-yl]ethanol 
• 27149-26-4 2-(4-chlorophenyl)thiazole 
• 1262511-86-3 2-[2-(4-chloro-phenyl)-5-ethyl-thiazol-4-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione 
• 1262512-65-1 2-[2-(4-chloro-phenyl)-5-ethyl-thiazol-4-yl]-5-[hydroxy-(tetrahydro-pyran-4-yl)methyl]-3-methoxy-cyclopent-2-enone 
• 1318071-96-3 2-[2-(4-chloro-phenyl)-5-ethyl-thiazol-4-yl]-3-methoxy-cyclopent-2-enone 
• 1262512-62-8 2-[2-(4-chloro-phenyl)-5-ethyl-thiazol-4-yl]cyclopentane-1,3-dione 
• 1262512-60-6 3-{1-[2-(4-chloro-phenyl)thiazol-5-yl]ethoxy}cyclopent-2-enone 
• 1262511-84-1 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-4-(5-fluoro-pyridin-2-ylmethyl)cyclopentane-1,3-dione 
• 1262512-57-1 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-4-[1-(5-fluoro-pyridin-2-yl)meth-(E)-ylidene]cyclopentane-1,3-dione 
• 1262512-55-9 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-5-[(5-fluoro-pyridin-2-yl)hydroxy-methyl]-3-methoxy-cyclopent-2-enone 
• 1262511-81-8 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-4-(tetrahydro-pyran-4-ylmethyl)cyclopentane-1,3-dione 
• 1262512-16-2 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione 
• 1262512-52-6 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-3-methoxy-5-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopent-2-enone 

Relevant academic research and scientific papers

CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.

Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.

HERBICIDALLY ACTIVE HETEROARYL-SΥBSTITΥTED CYCLIC DIONES OR DERIVATIVES THEREOF

The invention relates to a compound of formula (I), which is suitable for use as a herbicide wherein G is hydrogen or an agriculturally acceptable metal, sulfonium, ammonium or latentiating group; Q is a unsubstituted or substituted C3-C8 saturated or mono-unsaturated heterocyclyl containing at least one heteroatom selected from O, N and S, or Q is heteroaryl or substituted heteroaryl; m is 1, 2 or 3; and Het is an optionally substituted monocyclic or bicyclic heteroaromatic ring; and wherein the compound is optionally an agronomically acceptable salt thereof.

PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF

A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I) wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.

Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors

A novel series of CHK1 inhibitors based on thienopyridine template has been designed and synthesized. These inhibitors maintain critical hydrogen bonding with the hinge and conserved water in the ATP binding site. Several compounds show single digit nanomolar CHK1 activities. Compound 70 shows excellent enzymatic activity of 1 nM.

PYRAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES

The present invention relates to pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting or antagonizing the αVβ3 and/or the α Vβ5 integrin without significantly inhibitin