721920-84-9

Basic information

• Product Name: 2-(4-Chlorophenyl)thiazole-5-carbaldehyde
• Synonyms: 2-(4-CHLOROPHENYL)THIAZOLE-5-CARBALDEHYDE;2-(4-hydroxyphenyl)thiazole-5-carbaldehyde;2-(4-chlorophenyl)-1,3-thiazole-5-carbaldehyde
• CAS NO: 721920-84-9
• Molecular Formula: C₁₀H₆ClNOS
• Molecular Weight: 223.68
• EINECS: 200-258-5
• Product Categories: API intermediates
• Mol File: 721920-84-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 377.571oC at 760 mmHg
• Flash Point: 182.149oC
• Appearance: /
• Density: 1.389g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.14±0.10(Predicted)
• CAS DataBase Reference: 2-(4-Chlorophenyl)thiazole-5-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chlorophenyl)thiazole-5-carbaldehyde(721920-84-9)
• EPA Substance Registry System: 2-(4-Chlorophenyl)thiazole-5-carbaldehyde(721920-84-9)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 721920-84-9(Hazardous Substances Data)

Usage

General Description

"2-(4-Chlorophenyl)thiazole-5-carbaldehyde" is a synthetic organic compound characterized by the presence of a 4-chlorophenyl group attached to the 2 position of a thiazole ring, with a carbaldehyde group at the 5 position. Its chemical formula is C11H6ClNS and has a molecular mass of 225.69 g/mol. This chemical compound is commonly used in pharmaceutical and chemical research due to its heterocyclic structure, making it an important intermediate in the synthesis of a wide range of bioactive molecules. The properties of this chemical, such as stability and reactivity, are not well-documented; however, it should be handled with appropriate safety measures as with any chemical constituents.

InChI:InChI=1/C10H6ClNOS/c11-8-3-1-7(2-4-8)10-12-5-9(6-13)14-10/h1-6H

Upstream product

• 36437-19-1 2-chloromalonaldehyde 
• 2521-24-6 4-chlorothiobenzamide 
• 464192-28-7 2-bromo-1,3-thiazole-5-carbaldehyde 
• 1679-18-1 4-Chlorophenylboronic acid 
• 2065-75-0 2-Bromo-malonaldehyde 

Downstream Products

• 1369465-55-3 C₁₂H₈ClNO₂S 
• 27149-26-4 2-(4-chlorophenyl)thiazole 
• 1262511-86-3 2-[2-(4-chloro-phenyl)-5-ethyl-thiazol-4-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione 
• 1262512-65-1 2-[2-(4-chloro-phenyl)-5-ethyl-thiazol-4-yl]-5-[hydroxy-(tetrahydro-pyran-4-yl)methyl]-3-methoxy-cyclopent-2-enone 
• 1318071-96-3 2-[2-(4-chloro-phenyl)-5-ethyl-thiazol-4-yl]-3-methoxy-cyclopent-2-enone 
• 1262512-62-8 2-[2-(4-chloro-phenyl)-5-ethyl-thiazol-4-yl]cyclopentane-1,3-dione 
• 1262512-60-6 3-{1-[2-(4-chloro-phenyl)thiazol-5-yl]ethoxy}cyclopent-2-enone 
• 1262511-84-1 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-4-(5-fluoro-pyridin-2-ylmethyl)cyclopentane-1,3-dione 
• 1262512-57-1 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-4-[1-(5-fluoro-pyridin-2-yl)meth-(E)-ylidene]cyclopentane-1,3-dione 
• 1262512-55-9 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-5-[(5-fluoro-pyridin-2-yl)hydroxy-methyl]-3-methoxy-cyclopent-2-enone 
• 1262511-81-8 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-4-(tetrahydro-pyran-4-ylmethyl)cyclopentane-1,3-dione 
• 1262512-16-2 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione 
• 1262512-52-6 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-3-methoxy-5-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopent-2-enone 
• 1262512-50-4 2-[2-(4-chloro-phenyl)-5-methyl-thiazol-4-yl]-3-methoxy-cyclopent-2-enone 

Relevant articles and documents

Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.

HERBICIDALLY ACTIVE HETEROARYL-SΥBSTITΥTED CYCLIC DIONES OR DERIVATIVES THEREOF

The invention relates to a compound of formula (I), which is suitable for use as a herbicide wherein G is hydrogen or an agriculturally acceptable metal, sulfonium, ammonium or latentiating group; Q is a unsubstituted or substituted C3-C8 saturated or mono-unsaturated heterocyclyl containing at least one heteroatom selected from O, N and S, or Q is heteroaryl or substituted heteroaryl; m is 1, 2 or 3; and Het is an optionally substituted monocyclic or bicyclic heteroaromatic ring; and wherein the compound is optionally an agronomically acceptable salt thereof.

PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF

A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I) wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.