[2S,3RS]-toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)phenyl ester hydrochloride

Base Information

Chemical Name:[2S,3RS]-toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)phenyl ester hydrochloride
CAS No.:1369206-01-8
Molecular Formula:C₂₁H₂₉NO₄S*ClH
Molecular Weight:427.992
Hs Code.:

Synonyms:[2S,3RS]-toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)phenyl ester hydrochloride

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Chemical Property of [2S,3RS]-toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)phenyl ester hydrochloride

Chemical Property:

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Technology Process of [2S,3RS]-toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)phenyl ester hydrochloride

There total 8 articles about [2S,3RS]-toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)phenyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369205-82-2
[2S,3RS]-toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)phenyl ester

: 1369206-01-8
[2S,3RS]-toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)phenyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; di-isopropyl ether; at 20 ℃; for 0.25h;

Reference yield:

: 13103-80-5
1-(3-hydroxyphenyl)propan-1-one

: 1369206-01-8
[2S,3RS]-toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)phenyl ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / isopropyl alcohol; water / 16 h / Reflux

2.1: potassium carbonate / dichloromethane / 1 h / 30 - 35 °C

3.1: O,O'-dibenzoyl-L-tartaric acid / ethyl acetate / 5 h / 10 - 20 °C / Cooling

3.2: 1 h / 20 - 25 °C

4.1: tetrahydrofuran / 3 h / 25 - 30 °C

5.1: hydrogenchloride / di-isopropyl ether; methanol / 0.25 h / 20 °C

With hydrogenchloride; potassium carbonate; O,O'-dibenzoyl-L-tartaric acid; In tetrahydrofuran; methanol; dichloromethane; di-isopropyl ether; water; ethyl acetate; isopropyl alcohol;

Reference yield:

: 1343471-61-3
rac-3-(dimethylamino)-1-(3-hydroxyphenyl)-2-methylpropan-1-one

: 1369206-01-8
[2S,3RS]-toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)phenyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dichloromethane / 1 h / 30 - 35 °C

2.1: O,O'-dibenzoyl-L-tartaric acid / ethyl acetate / 5 h / 10 - 20 °C / Cooling

2.2: 1 h / 20 - 25 °C

3.1: tetrahydrofuran / 3 h / 25 - 30 °C

4.1: hydrogenchloride / di-isopropyl ether; methanol / 0.25 h / 20 °C

With hydrogenchloride; potassium carbonate; O,O'-dibenzoyl-L-tartaric acid; In tetrahydrofuran; methanol; dichloromethane; di-isopropyl ether; ethyl acetate;