phenyl-(2-pyrrol-1-yl-pyridin-3-yloxy)-acetic acid ethyl ester

Base Information

• Chemical Name: phenyl-(2-pyrrol-1-yl-pyridin-3-yloxy)-acetic acid ethyl ester
• CAS No.: 249741-89-7
• Molecular Formula: C₁₉H₁₈N₂O₃
• Molecular Weight: 322.364
• Mol file: 249741-89-7.mol

Synonyms:phenyl-(2-pyrrol-1-yl-pyridin-3-yloxy)-acetic acid ethyl ester

Chemical Property of phenyl-(2-pyrrol-1-yl-pyridin-3-yloxy)-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of phenyl-(2-pyrrol-1-yl-pyridin-3-yloxy)-acetic acid ethyl ester

There total 1 articles about phenyl-(2-pyrrol-1-yl-pyridin-3-yloxy)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydroxy-3 (pyrrolyl-1)-2 pyridine (102064-28-8) + ethyl 2-phenyl-2-bromoacetate (2882-19-1,2216-90-2) → phenyl-(2-pyrrol-1-yl-pyridin-3-yloxy)-acetic acid ethyl ester (249741-89-7)

Guidance literature:

hydroxy-3 (pyrrolyl-1)-2 pyridine; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

ethyl 2-phenyl-2-bromoacetate; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jm990150o

Reference yield:

phenyl-(2-pyrrol-1-yl-pyridin-3-yloxy)-acetic acid ethyl ester (249741-89-7) → phenyl-(2-pyrrol-1-yl-pyridin-3-yloxy)-acetic acid (249741-90-0)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 17h;

DOI:10.1021/jm990150o

Reference yield:

phenyl-(2-pyrrol-1-yl-pyridin-3-yloxy)-acetic acid ethyl ester (249741-89-7) → 5-ethyl-5-phenyl-6-oxa-10,10b-diaza-benzo[e]azulen-4-one (252010-39-2,400008-99-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 5 percent aq. NaOH / ethanol / 17 h / 20 °C

2: PCl₅ / 5 h / 20 °C

3: K₂CO₃

With sodium hydroxide; phosphorus pentachloride; potassium carbonate; In ethanol; 1: Hydrolysis / 2: Cyclization / 3: Alkylation;

DOI:10.1021/jm990150o

upstream raw materials:

hydroxy-3 (pyrrolyl-1)-2 pyridine

ethyl 2-phenyl-2-bromoacetate

Downstream raw materials:

phenyl-(2-pyrrol-1-yl-pyridin-3-yloxy)-acetic acid

(+/-)-6-Phenylpyrrolo[1,2-d]pyrido[3,2-b][1,4]oxazepin-7(6H)-one

5-ethyl-5-phenyl-6-oxa-10,10b-diaza-benzo[e]azulen-4-one