6-chloro-2-(2,2-dimethylpropyl)-3-(hydroxymethyl)-4-phenylisoquinolin-1(2H)-one

Base Information

• Chemical Name: 6-chloro-2-(2,2-dimethylpropyl)-3-(hydroxymethyl)-4-phenylisoquinolin-1(2H)-one
• CAS No.: 1332697-08-1
• Molecular Formula: C₂₁H₂₂ClNO₂
• Molecular Weight: 355.864
• Mol file: 1332697-08-1.mol

Synonyms:6-chloro-2-(2,2-dimethylpropyl)-3-(hydroxymethyl)-4-phenylisoquinolin-1(2H)-one

Chemical Property of 6-chloro-2-(2,2-dimethylpropyl)-3-(hydroxymethyl)-4-phenylisoquinolin-1(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 6-chloro-2-(2,2-dimethylpropyl)-3-(hydroxymethyl)-4-phenylisoquinolin-1(2H)-one

There total 1 articles about 6-chloro-2-(2,2-dimethylpropyl)-3-(hydroxymethyl)-4-phenylisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H19Cl2NO2 → 6-chloro-2-(2,2-dimethylpropyl)-3-(hydroxymethyl)-4-phenylisoquinolin-1(2H)-one (1332697-08-1)

Guidance literature:

C₂₁H₁₉Cl₂NO₂; With sodium tetrahydroborate; In tetrahydrofuran; 1,2-dimethoxyethane; at 0 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; 1,2-dimethoxyethane; water;

DOI:10.1016/j.bmc.2011.06.059

Reference yield:

6-chloro-2-(2,2-dimethylpropyl)-3-(hydroxymethyl)-4-phenylisoquinolin-1(2H)-one (1332697-08-1) + methanesulfonyl chloride (124-63-0) → C22H24ClNO4S

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmc.2011.06.059

Reference yield:

6-chloro-2-(2,2-dimethylpropyl)-3-(hydroxymethyl)-4-phenylisoquinolin-1(2H)-one (1332697-08-1) → 3-(aminomethyl)-6-chloro-2-(2,2-dimethylpropyl)-4-phenylisoquinolin-1(2H)-one (447415-86-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.5 h / 20 °C

2: ammonia / tetrahydrofuran; methanol / 6 h / 150 °C / Sealed tube

With ammonia; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.bmc.2011.06.059

Downstream raw materials:

3-(aminomethyl)-6-chloro-2-(2,2-dimethylpropyl)-4-phenylisoquinolin-1(2H)-one