syn-tert-butyl ((5S,6R)-6-methyl-2-oxo-5-phenylpiperidin-3-yl)carbamate

Base Information

• Chemical Name: syn-tert-butyl ((5S,6R)-6-methyl-2-oxo-5-phenylpiperidin-3-yl)carbamate
• CAS No.: 1375541-78-8
• Molecular Formula: C₁₇H₂₄N₂O₃
• Molecular Weight: 304.389
• Mol file: 1375541-78-8.mol

Synonyms:syn-tert-butyl ((5S,6R)-6-methyl-2-oxo-5-phenylpiperidin-3-yl)carbamate

Chemical Property of syn-tert-butyl ((5S,6R)-6-methyl-2-oxo-5-phenylpiperidin-3-yl)carbamate

Chemical Property:

Purity/Quality:

99.3% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of syn-tert-butyl ((5S,6R)-6-methyl-2-oxo-5-phenylpiperidin-3-yl)carbamate

There total 19 articles about syn-tert-butyl ((5S,6R)-6-methyl-2-oxo-5-phenylpiperidin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + tert-butyl [5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate → syn-tert-butyl ((5S,6R)-6-methyl-2-oxo-5-phenylpiperidin-3-yl)carbamate (1375541-78-8)

Guidance literature:

tert-butyl [5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate; With hydrogen; palladium 10% on activated carbon; In methanol; for 6.5h; under 760.051 Torr;

With hydrogen; triethylamine; palladium 10% on activated carbon; In ethanol; for 2.25h; under 2585.81 Torr;

di-tert-butyl dicarbonate;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + tert-butyl (3S)-[5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate (1375541-76-6) → syn-tert-butyl ((5S,6R)-6-methyl-2-oxo-5-phenylpiperidin-3-yl)carbamate (1375541-78-8)

Guidance literature:

tert-butyl (3S)-[5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate; With hydrogen; palladium 10% on activated carbon; In methanol; for 6.5h; under 760.051 Torr;

With hydrogen; triethylamine; palladium 10% on activated carbon; In ethanol; for 2.25h; under 2585.81 Torr;

di-tert-butyl dicarbonate;

Reference yield:

isopropyl (2S)-4-phenyl-2-(tert-butoxycarbonylamino)-5-oxohexanoate → syn-tert-butyl ((5S,6R)-6-methyl-2-oxo-5-phenylpiperidin-3-yl)carbamate (1375541-78-8) + tert-butyl (3R,5S,6R)-6-methyl-2-oxo-5-phenylpiperidin-3-ylcarbamate

Guidance literature:

With hydrogenchloride; borax; pyridoxal 5'-phosphate; isopropylamine; In water; dimethyl sulfoxide; at 55 ℃; for 24h; pH=10.5; Overall yield = 80 %; Overall yield = 99.6 g; Optical yield = 9.091 %de;

upstream raw materials:

di-tert-butyl dicarbonate

N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester

1-(4-chlorophenyl)propan-2-one

tert-butyl (3S)-[5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate

Downstream raw materials:

tert-butyl [(3S,5S,6R)-6-methyl-1-(2-methylprop-2-en-1-yl)-2-oxo-5-phenylpiperidin-3-yl]carbamate

tert-butyl [(3S,5S,6R)-6-methyl-1-(2-methylpropyl)-2-oxo-5-phenylpiperidin-3-yl]carbamate

(3S,5S,6R)-3-amino-6-methyl-1-(2-methylpropyl)-5-phenylpiperidin-2-one hydrochloride

(6S)-N-[(5R,6S,8S)-3-(2-hydroxypropan-2-yl)-5-methyl-6-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-yl]-6'-oxo-5,6',7,7'-tetrahydrospiro[cyclopenta[b]pyridine-6,5'-pyrrolo[2,3-b]pyrimidine]-3-carboxamide