tert-butyl (3S)-[5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate

Base Information

Chemical Name:tert-butyl (3S)-[5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate
CAS No.:1375541-76-6
Molecular Formula:C₁₇H₂₃ClN₂O₃
Molecular Weight:338.834
Hs Code.:

Synonyms:tert-butyl (3S)-[5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate

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Chemical Property of tert-butyl (3S)-[5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate

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Technology Process of tert-butyl (3S)-[5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate

There total 1 articles about tert-butyl (3S)-[5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-(4-chlorophenyl)-5-oxohexanoate

: 1375541-76-6
tert-butyl (3S)-[5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate

Guidance literature:: methyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-(4-chlorophenyl)-5-oxohexanoate; With ammonium acetate; sodium cyanoborohydride; acetic acid; In methanol; at 60 ℃; for 4h;

With potassium carbonate; In ethanol; at 60 ℃; for 1.5h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1375541-76-6
tert-butyl (3S)-[5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate

: 1375541-78-8
syn-tert-butyl ((5S,6R)-6-methyl-2-oxo-5-phenylpiperidin-3-yl)carbamate

Guidance literature:: tert-butyl (3S)-[5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate; With hydrogen; palladium 10% on activated carbon; In methanol; for 6.5h; under 760.051 Torr;

With hydrogen; triethylamine; palladium 10% on activated carbon; In ethanol; for 2.25h; under 2585.81 Torr;

di-tert-butyl dicarbonate;

Reference yield:

: 1375541-76-6
tert-butyl (3S)-[5-(4-chlorophenyl)-6-methyl-2-oxopiperidin-3-yl]carbamate

: 1383733-52-5
tert-butyl [(3S,5S,6R)-6-methyl-5-phenyl-2-thioxopiperidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 6.5 h / 760.05 Torr

1.2: 2.25 h / 2585.81 Torr

2.1: Lawessons reagent / toluene / 16 h / 40 °C

With Lawessons reagent; hydrogen; palladium 10% on activated carbon; In methanol; toluene;