4-[(2-hydroxy-1-methyl-2-phenylethyl)-methylcarbamoyl]-3-(4-methoxyphenoxymethyl)-4-phenylbutyric acid methyl ester

Base Information

Chemical Name:4-[(2-hydroxy-1-methyl-2-phenylethyl)-methylcarbamoyl]-3-(4-methoxyphenoxymethyl)-4-phenylbutyric acid methyl ester
CAS No.:440370-34-3
Molecular Formula:C₃₀H₃₅NO₆
Molecular Weight:505.611
Hs Code.:

Synonyms:4-[(2-hydroxy-1-methyl-2-phenylethyl)-methylcarbamoyl]-3-(4-methoxyphenoxymethyl)-4-phenylbutyric acid methyl ester

Suppliers and Price of 4-[(2-hydroxy-1-methyl-2-phenylethyl)-methylcarbamoyl]-3-(4-methoxyphenoxymethyl)-4-phenylbutyric acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[(2-hydroxy-1-methyl-2-phenylethyl)-methylcarbamoyl]-3-(4-methoxyphenoxymethyl)-4-phenylbutyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[(2-hydroxy-1-methyl-2-phenylethyl)-methylcarbamoyl]-3-(4-methoxyphenoxymethyl)-4-phenylbutyric acid methyl ester

There total 6 articles about 4-[(2-hydroxy-1-methyl-2-phenylethyl)-methylcarbamoyl]-3-(4-methoxyphenoxymethyl)-4-phenylbutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 96821-35-1
(E)-4-(4-methoxy-phenoxy)-but-2-enoic acid methyl ester

: 440370-33-2
N-((1R,2R)-2-hydroxy-1-methyl-2-phenylethyl)-N-methyl-2-phenylacetamide

: 440370-34-3
4-[(2-hydroxy-1-methyl-2-phenylethyl)-methylcarbamoyl]-3-(4-methoxyphenoxymethyl)-4-phenylbutyric acid methyl ester

: 4-[(2-hydroxy-1-methyl-2-phenylethyl)-methylcarbamoyl]-3-(4-methoxyphenoxymethyl)-4-phenylbutyric acid methyl ester

: 4-[(2-hydroxy-1-methyl-2-phenylethyl)-methylcarbamoyl]-3-(4-methoxyphenoxymethyl)-4-phenylbutyric acid methyl ester

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.666667h;
DOI:10.1021/jo035564a

Reference yield:

: 96821-35-1
(E)-4-(4-methoxy-phenoxy)-but-2-enoic acid methyl ester

: 440370-33-2
N-((1R,2R)-2-hydroxy-1-methyl-2-phenylethyl)-N-methyl-2-phenylacetamide

: 440370-34-3
4-[(2-hydroxy-1-methyl-2-phenylethyl)-methylcarbamoyl]-3-(4-methoxyphenoxymethyl)-4-phenylbutyric acid methyl ester

: 4-[(2-hydroxy-1-methyl-2-phenylethyl)-methylcarbamoyl]-3-(4-methoxyphenoxymethyl)-4-phenylbutyric acid methyl ester

Guidance literature:: With lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.666667h; Title compound not separated from byproducts;
DOI:10.1021/jo035564a

Reference yield:

: 1117-71-1,56699-18-4,6000-00-6
methyl-4-bromo-2-butenoate

: 440370-34-3
4-[(2-hydroxy-1-methyl-2-phenylethyl)-methylcarbamoyl]-3-(4-methoxyphenoxymethyl)-4-phenylbutyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / K₂CO₃ / acetone; H₂O / 17 h / 20 °C

2: lithium bis(trimethylsilyl)amide; LiCl / tetrahydrofuran / 0.67 h / -78 °C

With potassium carbonate; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; water; acetone; 2: Michael addition;
DOI:10.1021/jo035564a