ethyl 2-(8-benzyl-8-azabicyclo[3.2.1]octan-3-ylidene)acetate

Base Information

• Chemical Name: ethyl 2-(8-benzyl-8-azabicyclo[3.2.1]octan-3-ylidene)acetate
• CAS No.: 79521-85-0
• Molecular Formula: C₁₈H₂₃NO₂
• Molecular Weight: 285.386
• Mol file: 79521-85-0.mol

Synonyms:ethyl 2-(8-benzyl-8-azabicyclo[3.2.1]octan-3-ylidene)acetate

Chemical Property of ethyl 2-(8-benzyl-8-azabicyclo[3.2.1]octan-3-ylidene)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(8-benzyl-8-azabicyclo[3.2.1]octan-3-ylidene)acetate

There total 3 articles about ethyl 2-(8-benzyl-8-azabicyclo[3.2.1]octan-3-ylidene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

(8-azabicyclo[3.2.1]oct-3-ylidene)acetic acid ethyl ester (122860-04-2) + benzyl bromide (100-39-0) → ethyl 2-(8-benzyl-8-azabicyclo[3.2.1]octan-3-ylidene)acetate (79521-85-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

Boc-tropinone (185099-67-6) → ethyl 2-(8-benzyl-8-azabicyclo[3.2.1]octan-3-ylidene)acetate (79521-85-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.67 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: pH 13

3.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

With sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

tert-butyl 3-(2-ethoxy-2-oxoethylidene)-8-azabicyclo[3.2.1]octane-8-carboxylate (865106-60-1) → ethyl 2-(8-benzyl-8-azabicyclo[3.2.1]octan-3-ylidene)acetate (79521-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

1.2: pH 13

2.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

upstream raw materials:

(8-azabicyclo[3.2.1]oct-3-ylidene)acetic acid ethyl ester

benzyl bromide

Boc-tropinone

tert-butyl 3-(2-ethoxy-2-oxoethylidene)-8-azabicyclo[3.2.1]octane-8-carboxylate

Downstream raw materials:

2-(8-benzyl-8-azabicyclo[3.2.1]octan-3-ylidene)-N-hydroxyacetamide