(E)-(1R,8S,9R,10S,12R,13R,17S,19S,20R,21S,23R)-13-Allyl-1,10,12-trihydroxy-8-[(E)-2-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-19,21-dimethoxy-4,9,15,17,23-pentamethyl-7,24-dioxa-4-aza-bicyclo[18.3.1]tetracos-14-ene-2,3,6-trione

Base Information

Chemical Name:(E)-(1R,8S,9R,10S,12R,13R,17S,19S,20R,21S,23R)-13-Allyl-1,10,12-trihydroxy-8-[(E)-2-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-19,21-dimethoxy-4,9,15,17,23-pentamethyl-7,24-dioxa-4-aza-bicyclo[18.3.1]tetracos-14-ene-2,3,6-trione
CAS No.:129873-45-6
Molecular Formula:C₄₁H₆₇NO₁₂
Molecular Weight:765.982
Hs Code.:

(E)-(1R,8S,9R,10S,12R,13R,17S,19S,20R,21S,23R)-13-Allyl-1,10,12-trihydroxy-8-[(E)-2-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-19,21-dimethoxy-4,9,15,17,23-pentamethyl-7,24-dioxa-4-aza-bicyclo[18.3.1]tetracos-14-ene-2,3,6-trione

Synonyms:(E)-(1R,8S,9R,10S,12R,13R,17S,19S,20R,21S,23R)-13-Allyl-1,10,12-trihydroxy-8-[(E)-2-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-19,21-dimethoxy-4,9,15,17,23-pentamethyl-7,24-dioxa-4-aza-bicyclo[18.3.1]tetracos-14-ene-2,3,6-trione

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Chemical Property of (E)-(1R,8S,9R,10S,12R,13R,17S,19S,20R,21S,23R)-13-Allyl-1,10,12-trihydroxy-8-[(E)-2-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-19,21-dimethoxy-4,9,15,17,23-pentamethyl-7,24-dioxa-4-aza-bicyclo[18.3.1]tetracos-14-ene-2,3,6-trione

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Technology Process of (E)-(1R,8S,9R,10S,12R,13R,17S,19S,20R,21S,23R)-13-Allyl-1,10,12-trihydroxy-8-[(E)-2-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-19,21-dimethoxy-4,9,15,17,23-pentamethyl-7,24-dioxa-4-aza-bicyclo[18.3.1]tetracos-14-ene-2,3,6-trione

There total 2 articles about (E)-(1R,8S,9R,10S,12R,13R,17S,19S,20R,21S,23R)-13-Allyl-1,10,12-trihydroxy-8-[(E)-2-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-19,21-dimethoxy-4,9,15,17,23-pentamethyl-7,24-dioxa-4-aza-bicyclo[18.3.1]tetracos-14-ene-2,3,6-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 131364-06-2
C₇₁H₁₃₅NO₁₂Si₄

: 129873-45-6
(E)-(1R,8S,9R,10S,12R,13R,17S,19S,20R,21S,23R)-13-Allyl-1,10,12-trihydroxy-8-[(E)-2-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-19,21-dimethoxy-4,9,15,17,23-pentamethyl-7,24-dioxa-4-aza-bicyclo[18.3.1]tetracos-14-ene-2,3,6-trione

Guidance literature:: With hydrogen fluoride; In acetonitrile;
DOI:10.1021/jo00307a013

Reference yield:

: 131364-04-0
C₇₁H₁₃₉NO₁₂Si₄

: 129873-45-6
(E)-(1R,8S,9R,10S,12R,13R,17S,19S,20R,21S,23R)-13-Allyl-1,10,12-trihydroxy-8-[(E)-2-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-19,21-dimethoxy-4,9,15,17,23-pentamethyl-7,24-dioxa-4-aza-bicyclo[18.3.1]tetracos-14-ene-2,3,6-trione

Guidance literature:: Multi-step reaction with 2 steps

1: Swern oxidation

2: 87 percent / HF / acetonitrile

With hydrogen fluoride; In acetonitrile;
DOI:10.1021/jo00307a013

Reference yield:

: 129873-45-6
(E)-(1R,8S,9R,10S,12R,13R,17S,19S,20R,21S,23R)-13-Allyl-1,10,12-trihydroxy-8-[(E)-2-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-19,21-dimethoxy-4,9,15,17,23-pentamethyl-7,24-dioxa-4-aza-bicyclo[18.3.1]tetracos-14-ene-2,3,6-trione

: 129873-36-5
(E)-(1R,8S,9R,10S,13R,17S,19S,20R,21S,23R)-13-Allyl-1,10-dihydroxy-8-[(E)-2-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-19,21-dimethoxy-4,9,15,17,23-pentamethyl-7,24-dioxa-4-aza-bicyclo[18.3.1]tetracos-14-ene-2,3,6,12-tetraone

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine

2: Dess-Martin oxidation

3: HF / acetonitrile

With pyridine; hydrogen fluoride; In acetonitrile;
DOI:10.1021/jo00307a013