(R)-2-((3S,5R)-3-Ethyl-5-hydroxymethyl-isoxazolidin-2-yl)-2-phenyl-ethanol

Base Information

Chemical Name:(R)-2-((3S,5R)-3-Ethyl-5-hydroxymethyl-isoxazolidin-2-yl)-2-phenyl-ethanol
CAS No.:623582-49-0
Molecular Formula:C₁₄H₂₁NO₃
Molecular Weight:251.326
Hs Code.:

Synonyms:(R)-2-((3S,5R)-3-Ethyl-5-hydroxymethyl-isoxazolidin-2-yl)-2-phenyl-ethanol

Suppliers and Price of (R)-2-((3S,5R)-3-Ethyl-5-hydroxymethyl-isoxazolidin-2-yl)-2-phenyl-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-((3S,5R)-3-Ethyl-5-hydroxymethyl-isoxazolidin-2-yl)-2-phenyl-ethanol

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Technology Process of (R)-2-((3S,5R)-3-Ethyl-5-hydroxymethyl-isoxazolidin-2-yl)-2-phenyl-ethanol

There total 1 articles about (R)-2-((3S,5R)-3-Ethyl-5-hydroxymethyl-isoxazolidin-2-yl)-2-phenyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 123-38-6
propionaldehyde

: 107-18-6
allyl alcohol

: 321174-47-4
(R)-α-(hydroxymethyl)benzylhydroxylamine

: (R)-2-((3R,5S)-3-Ethyl-5-hydroxymethyl-isoxazolidin-2-yl)-2-phenyl-ethanol

: 623582-49-0
(R)-2-((3S,5R)-3-Ethyl-5-hydroxymethyl-isoxazolidin-2-yl)-2-phenyl-ethanol

Guidance literature:: With isopropyl alcohol; magnesium bromide; In tetrahydrofuran; at 65 ℃; for 72h;
DOI:10.1021/jo034940o

Reference yield:

: 623582-49-0
(R)-2-((3S,5R)-3-Ethyl-5-hydroxymethyl-isoxazolidin-2-yl)-2-phenyl-ethanol

: 183990-48-9,557091-78-8
(S)-3-(N-tert-butoxycarbonylamino)pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd(OH)2/C / methanol / 760 Torr

2: 190 mg / NaHCO₃ / tetrahydrofuran; H₂O / 20 °C

3: 92 percent / NaIO₄ / RuCl₃*H₂O / acetonitrile; H₂O / 0.75 h / 20 °C

With sodium periodate; hydrogen; sodium hydrogencarbonate; ruthenium trichloride; palladium dihydroxide; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1021/jo034940o