Technology Process of bis-(2-(15-allyloxy-pentadecyloxymethoxy)-ethyl)-trityl-amine
There total 7 articles about bis-(2-(15-allyloxy-pentadecyloxymethoxy)-ethyl)-trityl-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
15-(2-((2-(15-hydroxy-pentadecyloxymethoxy)-ethyl)-trityl-amino)-ethoxymethoxy)-pentadecan-1-ol;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
allyl iodid;
With
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran;
for 4h;
Heating;
DOI:10.1021/jo0493020
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 87 percent / Amberlyst A-15 / 48 h / Heating
2.1: chlorotrimethylsilane / CH2Cl2 / 1.33 h / 20 °C
3.1: 82 percent / diisopropylethylamine; tetrabutylammonium iodide / tetrahydrofuran / 6 h / Heating
4.1: 91 percent / LiAlH4 / tetrahydrofuran / Heating
5.1: NaH / tetrahydrofuran / 1 h / 0 °C
5.2: 90 percent / tetrabutylammonium iodide / tetrahydrofuran / 4 h / Heating
With
lithium aluminium tetrahydride; chloro-trimethyl-silane; Amberlyst A-15; tetra-(n-butyl)ammonium iodide; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0493020
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: chlorotrimethylsilane / CH2Cl2 / 1.33 h / 20 °C
2.1: 82 percent / diisopropylethylamine; tetrabutylammonium iodide / tetrahydrofuran / 6 h / Heating
3.1: 91 percent / LiAlH4 / tetrahydrofuran / Heating
4.1: NaH / tetrahydrofuran / 1 h / 0 °C
4.2: 90 percent / tetrabutylammonium iodide / tetrahydrofuran / 4 h / Heating
With
lithium aluminium tetrahydride; chloro-trimethyl-silane; tetra-(n-butyl)ammonium iodide; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0493020
