4-(ethoxycarbonyl)-2-formyl-3-mesitylpyrrole

Base Information

• Chemical Name: 4-(ethoxycarbonyl)-2-formyl-3-mesitylpyrrole
• CAS No.: 1394980-10-9
• Molecular Formula: C₁₇H₁₉NO₃
• Molecular Weight: 285.343
• Mol file: 1394980-10-9.mol

Synonyms:4-(ethoxycarbonyl)-2-formyl-3-mesitylpyrrole

Chemical Property of 4-(ethoxycarbonyl)-2-formyl-3-mesitylpyrrole

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-(ethoxycarbonyl)-2-formyl-3-mesitylpyrrole

There total 2 articles about 4-(ethoxycarbonyl)-2-formyl-3-mesitylpyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

3-(ethoxycarbonyl)-4-mesitylpyrrole (289882-61-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-(ethoxycarbonyl)-2-formyl-3-mesitylpyrrole (1394980-10-9)

Guidance literature:

3-(ethoxycarbonyl)-4-mesitylpyrrole; N,N-dimethyl-formamide; With trichlorophosphate; In dichloromethane; at 0 - 20 ℃; for 19h; Inert atmosphere;

With sodium hydroxide; In dichloromethane; water; at 0 ℃; Inert atmosphere;

DOI:10.1021/ic301262k

Reference yield:

ethyl 3-mesityl-2-propenoate → 4-(ethoxycarbonyl)-2-formyl-3-mesitylpyrrole (1394980-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / diethyl ether; dimethyl sulfoxide; mineral oil; tetrahydrofuran / 2.5 h / Inert atmosphere

2.1: trichlorophosphate / dichloromethane / 19 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

With sodium hydride; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; mineral oil; 2.1: |Vilsmeier Reaction;

DOI:10.1021/ic301262k

Reference yield: 80.0%

nitromethane (75-52-5) + 4-(ethoxycarbonyl)-2-formyl-3-mesitylpyrrole (1394980-10-9) → 4-(ethoxycarbonyl)-3-mesityl-2-(2-nitrovinyl)pyrrole (1394980-11-0)

Guidance literature:

With propylamine; acetic acid; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 3.25h; Inert atmosphere;

DOI:10.1021/ic301262k

upstream raw materials:

3-(ethoxycarbonyl)-4-mesitylpyrrole

N,N-dimethyl-formamide

Downstream raw materials:

4-(ethoxycarbonyl)-3-mesityl-2-(2-nitroethyl)pyrrole

6-(4-(ethoxycarbonyl)-3-mesitylpyrrol-2-yl)-1,1-dimethoxy-4,4-dimethyl-5-nitrohexan-2-one

Zn(II)-3,13-bis(ethoxycarbonyl)-2,12-dimesityl-5-methoxy-8,8,18,18-tetramethylbacteriochlorin

Cu(II)-3,13-bis(ethoxycarbonyl)-2,12-dimesityl-5-methoxy-8,8,18,18-tetramethylbacteriochlorin

Refernces