Technology Process of 6-(4-(ethoxycarbonyl)-3-mesitylpyrrol-2-yl)-1,1-dimethoxy-4,4-dimethyl-5-nitrohexan-2-one
There total 5 articles about 6-(4-(ethoxycarbonyl)-3-mesitylpyrrol-2-yl)-1,1-dimethoxy-4,4-dimethyl-5-nitrohexan-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
dichloromethane;
at 20 ℃;
for 7h;
Inert atmosphere;
DOI:10.1021/ic301262k
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / diethyl ether; dimethyl sulfoxide; mineral oil; tetrahydrofuran / 2.5 h / Inert atmosphere
2.1: trichlorophosphate / dichloromethane / 19 h / 0 - 20 °C / Inert atmosphere
2.2: 0 °C / Inert atmosphere
3.1: propylamine; acetic acid / tetrahydrofuran; methanol / 3.25 h / 0 - 20 °C / Inert atmosphere
4.1: silica gel; sodium tetrahydroborate / chloroform; isopropyl alcohol / 0.67 h
5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 7 h / 20 °C / Inert atmosphere
With
propylamine; sodium tetrahydroborate; silica gel; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; dimethyl sulfoxide; isopropyl alcohol; mineral oil;
2.1: |Vilsmeier Reaction / 3.1: |Henry Nitro Aldol Condensation / 5.1: |Michael Addition;
DOI:10.1021/ic301262k
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trichlorophosphate / dichloromethane / 19 h / 0 - 20 °C / Inert atmosphere
1.2: 0 °C / Inert atmosphere
2.1: propylamine; acetic acid / tetrahydrofuran; methanol / 3.25 h / 0 - 20 °C / Inert atmosphere
3.1: silica gel; sodium tetrahydroborate / chloroform; isopropyl alcohol / 0.67 h
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 7 h / 20 °C / Inert atmosphere
With
propylamine; sodium tetrahydroborate; silica gel; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; isopropyl alcohol;
1.1: |Vilsmeier Reaction / 2.1: |Henry Nitro Aldol Condensation / 4.1: |Michael Addition;
DOI:10.1021/ic301262k