N-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine

Base Information

Chemical Name:N-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine
CAS No.:565446-67-5
Molecular Formula:C₄₄H₄₁N₇O₅S
Molecular Weight:779.919
Hs Code.:

<i>N</i>-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-<i>N</i>'-benzoyl-<i>N</i>''-[3-(1-trityl-1<i>H</i>-imidazol-4-yl)-propyl]-guanidine

Synonyms:N-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine

There total 19 articles about N-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 98384-57-7
3,4-di(benzenesulfonyl)-1,2,5-oxadiazole

: 565446-54-0
N-benzoyl-N'-(3-hydroxypropyl)-N-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}guanidine

: 565446-67-5
N-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 - 25 ℃; for 2h;
DOI:10.1016/S0968-0896(02)00651-X

Reference yield:

: 96797-15-8
N-trityl-4⁽⁵⁾-iodoimidazole

: 565446-67-5
N-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: EtMgBr / CH₂Cl₂; diethyl ether / 0.5 h / 20 °C

1.2: 82 percent / CH₂Cl₂; diethyl ether / 0.5 h / 20 °C

2.1: NaNH₂ / tetrahydrofuran / Heating

3.1: H₂ / Pd/C / tetrahydrofuran

4.1: LiAlH₄; AlCl₃ / diethyl ether; tetrahydrofuran / 1 h / 20 °C

5.1: 86 percent / CH₂Cl₂ / 0.5 h / 20 °C

6.1: 61 percent / tetrahydrofuran / 0.67 h / Heating

7.1: 90 percent / aq. NaOH / tetrahydrofuran / 2 h / 20 - 25 °C

With sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; ethylmagnesium bromide; hydrogen; sodium amide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0968-0896(02)00651-X

Reference yield:

: 154312-79-5
1-trityl-4-(2-cyanoethyl)imidazole

: 565446-67-5
N-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / tetrahydrofuran

2: LiAlH₄; AlCl₃ / diethyl ether; tetrahydrofuran / 1 h / 20 °C

3: 86 percent / CH₂Cl₂ / 0.5 h / 20 °C

4: 61 percent / tetrahydrofuran / 0.67 h / Heating

5: 90 percent / aq. NaOH / tetrahydrofuran / 2 h / 20 - 25 °C

With sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0968-0896(02)00651-X