N-benzoyl-N'-(3-hydroxypropyl)-N-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}guanidine

Base Information

• Chemical Name: N-benzoyl-N'-(3-hydroxypropyl)-N-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}guanidine
• CAS No.: 565446-54-0
• Molecular Formula: C₃₆H₃₇N₅O₂
• Molecular Weight: 571.722
• Mol file: 565446-54-0.mol

Synonyms:N-benzoyl-N'-(3-hydroxypropyl)-N-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}guanidine

Chemical Property of N-benzoyl-N'-(3-hydroxypropyl)-N-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}guanidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzoyl-N'-(3-hydroxypropyl)-N-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}guanidine

There total 17 articles about N-benzoyl-N'-(3-hydroxypropyl)-N-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

propan-1-ol-3-amine (156-87-6) + 1-benzoyl-2-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}-O-phenylisourea (565446-50-6) → N-benzoyl-N'-(3-hydroxypropyl)-N-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}guanidine (565446-54-0)

Guidance literature:

In tetrahydrofuran; for 0.666667h; Heating;

DOI:10.1016/S0968-0896(02)00651-X

Reference yield:

N-trityl-4(5)-iodoimidazole (96797-15-8) → N-benzoyl-N'-(3-hydroxypropyl)-N-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}guanidine (565446-54-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: EtMgBr / CH₂Cl₂; diethyl ether / 0.5 h / 20 °C

1.2: 82 percent / CH₂Cl₂; diethyl ether / 0.5 h / 20 °C

2.1: NaNH₂ / tetrahydrofuran / Heating

3.1: H₂ / Pd/C / tetrahydrofuran

4.1: LiAlH₄; AlCl₃ / diethyl ether; tetrahydrofuran / 1 h / 20 °C

5.1: 86 percent / CH₂Cl₂ / 0.5 h / 20 °C

6.1: 61 percent / tetrahydrofuran / 0.67 h / Heating

With lithium aluminium tetrahydride; aluminium trichloride; ethylmagnesium bromide; hydrogen; sodium amide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/S0968-0896(02)00651-X

Reference yield:

1-trityl-4-(2-cyanoethyl)imidazole (154312-79-5) → N-benzoyl-N'-(3-hydroxypropyl)-N-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}guanidine (565446-54-0)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Pd/C / tetrahydrofuran

2: LiAlH₄; AlCl₃ / diethyl ether; tetrahydrofuran / 1 h / 20 °C

3: 86 percent / CH₂Cl₂ / 0.5 h / 20 °C

4: 61 percent / tetrahydrofuran / 0.67 h / Heating

With lithium aluminium tetrahydride; aluminium trichloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/S0968-0896(02)00651-X

upstream raw materials:

propan-1-ol-3-amine

1-benzoyl-2-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}-O-phenylisourea

N-diphenoxymethylene benzamide

N-trityl-4⁽⁵⁾-iodoimidazole

Downstream raw materials:

N-benzoyl-N'-[3-(4-phenyl-furazan-3-yloxy)-propyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine

N-benzoyl-N'-[3-(5-oxy-4-phenyl-furazan-3-yloxy)-propyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine

N-[3-(4-benzenesulfonyl-5-oxy-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine

N-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine