6-[2-(4-methyl-oxazole-5-carbonyl)-phenyl]-hept-2-en-4-ynoic acid ethyl ester

Base Information

Chemical Name:6-[2-(4-methyl-oxazole-5-carbonyl)-phenyl]-hept-2-en-4-ynoic acid ethyl ester
CAS No.:911297-49-9
Molecular Formula:C₂₀H₁₉NO₄
Molecular Weight:337.375
Hs Code.:

Synonyms:6-[2-(4-methyl-oxazole-5-carbonyl)-phenyl]-hept-2-en-4-ynoic acid ethyl ester

Suppliers and Price of 6-[2-(4-methyl-oxazole-5-carbonyl)-phenyl]-hept-2-en-4-ynoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-[2-(4-methyl-oxazole-5-carbonyl)-phenyl]-hept-2-en-4-ynoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-[2-(4-methyl-oxazole-5-carbonyl)-phenyl]-hept-2-en-4-ynoic acid ethyl ester

There total 11 articles about 6-[2-(4-methyl-oxazole-5-carbonyl)-phenyl]-hept-2-en-4-ynoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 911297-48-8
(4-methyl-oxazol-5-yl)-[2-(1-methyl-prop-2-ynyl)-phenyl]methanone

: 31930-36-6
ethyl (Z)-3-iodopropenoate

: 911297-49-9
6-[2-(4-methyl-oxazole-5-carbonyl)-phenyl]-hept-2-en-4-ynoic acid ethyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1021/ol061697h

Reference yield:

: 911297-37-5
2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenol

: 911297-49-9
6-[2-(4-methyl-oxazole-5-carbonyl)-phenyl]-hept-2-en-4-ynoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 24.88 g / N,N-dimethylaminopyridine; pyridine / CH₂Cl₂ / 0.5 h / 20 °C

2: 86 percent / Pd(OAc)2; bis[2-(diphenylphosphino)phenyl] ether; Et₃N / dioxane / 19 h / 60 °C

3: NaIO₄; AcOH / tetrahydrofuran / 65 h / 45 °C

4: 78 percent / PdCl₂(PPh₃)2; K₃PO₄*H₂O / toluene / 2 h / 60 °C

5: 97 percent / K₂CO₃ / methanol / 1 h / 20 °C

6: 63 percent / N,N-diisopropylethylamine; PdCl₂(PPh₃)2; CuI / tetrahydrofuran / 4 h / 20 °C

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; potassium phosphate; sodium periodate; copper(l) iodide; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; bis[2-(diphenylphosphino)phenyl] ether; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; 4: Suzuki reaction / 6: Sonogashira reaction;
DOI:10.1021/ol061697h

Reference yield:

: 911297-40-0
2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenylboronic acid

: 911297-49-9
6-[2-(4-methyl-oxazole-5-carbonyl)-phenyl]-hept-2-en-4-ynoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / PdCl₂(PPh₃)2; K₃PO₄*H₂O / toluene / 2 h / 60 °C

2: 97 percent / K₂CO₃ / methanol / 1 h / 20 °C

3: 63 percent / N,N-diisopropylethylamine; PdCl₂(PPh₃)2; CuI / tetrahydrofuran / 4 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; toluene; 1: Suzuki reaction / 3: Sonogashira reaction;
DOI:10.1021/ol061697h